Fungal Allergen and Mold Allergy Diagnosis: Role and Relevance of Alt a 1 Protein Family.

J Fungi (Basel)

Department of Immunology, Microbiology and Parasitology, Faculty of Pharmacy and Laboratory of Parasitology and Immunoallergy, Lascaray Research Centre, University of the Basque Country, 01006 Vitoria-Gasteiz, Spain.

Published: March 2022

is a genus of worldwide fungi found in different habitats such as soil, the atmosphere, plants or indoor environments. species are saprobic-largely involved in the decomposition of organic material-but they can also act as animal pathogens, causing disease in humans and animals, developing infections, toxicosis and allergic diseases. is considered one of the most important sources of fungal allergens worldwide and it is associated with severe asthma and respiratory status. Among the allergens, Alt a 1 is the main sensitizing allergen and its usefulness in diagnosis and immunotherapy has been demonstrated. Alt a 1 seems to define a protein family that can be used to identify related pathogenic fungi in plants and fruits, and to establish taxonomic relationships between the different fungal divisions.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954643PMC
http://dx.doi.org/10.3390/jof8030277DOI Listing

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