In real engineering applications, machine parts are rarely completely homogeneous; in most cases, there are at least some minor notch effects or even more extensive inhomogeneities, which cause critical local stress concentrations from which fatigue fractures develop. In the present research, a shift of the Coffin-Manson - material curve in a structure with random porosity subjected to dynamic LCF loads was studied. This allows the rest of the fatigue life prediction process to remain the same as if it were a homogeneous material. Apart from the cyclic - curve, which is relatively easy to obtain experimentally, the - curve is the second most important curve to describe the correlation between the fatigue life and the strain level . Therefore, the correct shift of the - curve of the homogeneous material to a position corresponding to the porous state of the material is crucial. We have found that the curve shift can be efficiently performed on the basis of numerical simulations of a combination of five porosity-specific geometric influences and the associated regression analysis. To model the modified synthetic - curve, five geometric influences of porosity by X-ray or -CT analysis are quantified, and then the porosity-adjusted coefficients of the Coffin-Manson equation are calculated. The proposed approach has been successfully applied to standard specimens with different porosity topography.
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http://dx.doi.org/10.3390/ma15062269 | DOI Listing |
Endocr Metab Immune Disord Drug Targets
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Department of Stomatology, The Affiliated Huaian No.1 People's Hospital, Nanjing Medical University, No.1 Huanghe West Road, Huaian, 223300, Jiangsu Province, China.
Background: Crohn's Disease (CD) is a chronic inflammatory gastrointestinal disease. Ustekinumab (UST) has been utilized as a therapeutic option for CD patients. However, approximately 40-60% of patients exhibit an inadequate response to UST.
View Article and Find Full Text PDFCurr Med Imaging
January 2025
Department of Radiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China.
Objective: The aim of this study was to develop and validate predictive models for perineural invasion (PNI) in gastric cancer (GC) using clinical factors and radiomics features derived from contrast-enhanced computed tomography (CE-CT) scans and to compare the performance of these models.
Methods: This study included 205 GC patients, who were randomly divided into a training set (n=143) and a validation set (n=62) in a 7:3 ratio. Optimal radiomics features were selected using the least absolute shrinkage and selection operator (LASSO) algorithm.
J Antimicrob Chemother
January 2025
Department of Infectious Diseases and Clinical Microbiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Objectives: To develop a scoring system to predict resistance to ceftolozane/tazobactam in Pseudomonas aeruginosa strains isolated from respiratory specimens.
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Integr Cancer Ther
January 2025
Department of Physiotherapy, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Background: Adherence in rehabilitation services includes attending appointments, regularly performing prescribed exercises, and correct exercise execution. The Exercise Adherence Rating Scale (EARS) has been adapted into several languages, but there is lack of a standardized tool for various Indian languages and cultural contexts, particularly for use with cancer survivors. With the anticipated 57.
View Article and Find Full Text PDFJ Clin Transl Endocrinol
March 2025
Department of Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, PR China.
Objectives: This study aimed to evaluate the diagnostic performance for medullary thyroid cancer (MTC) based on the 2017 Thyroid Imaging Reporting and Data System by the American College of Radiology (ACR TI-RADS) guideline, and the ability to recommend fine needle aspiration (FNA) for MTC.
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