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Advances in High Throughput Proteomics Profiling in Establishing Potential Biomarkers for Gastrointestinal Cancer. | LitMetric

Advances in High Throughput Proteomics Profiling in Establishing Potential Biomarkers for Gastrointestinal Cancer.

Cells

Department of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China.

Published: March 2022

AI Article Synopsis

  • - Gastrointestinal cancers (GICs) are the most common cancer type and lead to the highest number of cancer-related deaths worldwide, primarily due to late-stage diagnosis and poor treatment outcomes stemming from ineffective early diagnostic biomarkers.
  • - Current biomarkers for GICs lack the necessary specificity and sensitivity, necessitating the development of better biomarkers to improve early detection and treatment.
  • - This review highlights recent advancements in mass spectrometry and proteomics, aiming to establish more reliable biomarkers for various types of GICs while also addressing challenges in clinically validating these new proteomics-based biomarkers.

Article Abstract

Gastrointestinal cancers (GICs) remain the most diagnosed cancers and accounted for the highest cancer-related death globally. The prognosis and treatment outcomes of many GICs are poor because most of the cases are diagnosed in advanced metastatic stages. This is primarily attributed to the deficiency of effective and reliable early diagnostic biomarkers. The existing biomarkers for GICs diagnosis exhibited inadequate specificity and sensitivity. To improve the early diagnosis of GICs, biomarkers with higher specificity and sensitivity are warranted. Proteomics study and its functional analysis focus on elucidating physiological and biological functions of unknown or annotated proteins and deciphering cellular mechanisms at molecular levels. In addition, quantitative analysis of translational proteomics is a promising approach in enhancing the early identification and proper management of GICs. In this review, we focus on the advances in mass spectrometry along with the quantitative and functional analysis of proteomics data that contributes to the establishment of biomarkers for GICs including, colorectal, gastric, hepatocellular, pancreatic, and esophageal cancer. We also discuss the future challenges in the validation of proteomics-based biomarkers for their translation into clinics.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946849PMC
http://dx.doi.org/10.3390/cells11060973DOI Listing

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