AI Article Synopsis
- The hexane fraction of Fuzhuan brick tea shows an anti-graying effect by reducing reactive oxygen species (ROS) in Melan-A cells, which are linked to decreased melanin production in hair follicles.
- The tea increases cellular tyrosinase levels and melanin content, enhancing the expression of key proteins involved in melanogenesis and activating the MAP-kinase pathway.
- Major components of the hexane fraction include gallic acid, theaflavin, theobromine, caffeine, epicatechin, and quercetin, suggesting that Fuzhuan brick tea can help protect against hair pigment loss caused by ROS damage.
Article Abstract
The anti-graying effect of the hexane fraction of Fuzhuan brick tea is investigated in Melan-A cells and C57BL/6 mice. As a result, it is found that reactive oxygen species-induced damage is associated with the reduction of melanogenesis in hair bulb melanocytes when reactive oxygen species generation in Melan-A cells occurred. The results revealed that the hexane fraction of Fuzhuan brick tea could remarkably reduce reactive oxygen species generation in Melan-A cells; meanwhile, it could increase the cellular tyrosinase and melanin content, as well as up-regulate the expression of tyrosinase, tyrosinase related protein-1, tyrosinase related protein-2, and microphthalmia-associated transcription factor, and activate the MAP-kinase pathway through activating the phosphorylation of p38 c-Jun N terminal kinase/extracellular signal-regulated kinase. Furthermore, high-pressure liquid chromatography analysis reveals that the tea's major ingredients in hexane fraction include gallic acid, theaflavin, theobromine, caffeine, epicatechin, and quercetin. Together, the current results suggest that Fuzhuan brick tea proves to protect from the damage of hydroquinone, which induces hair pigment loss.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8945210 | PMC |
| http://dx.doi.org/10.3390/antiox11030599 | DOI Listing |
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