Objective: To investigate changes in the level of gamma-aminobutyric acid (GABA) in the left dorsolateral prefrontal cortex (DLPFC) of patients with chronic insomnia treated with real repetitive transcranial magnetic stimulation (rTMS) as compared to sham-rTMS, as measured with H-Magnetic Resonance Spectroscopy (H-MRS).
Methods: Forty chronic insomnia participants were randomized to either real or sham rTMS group. The rTMS was administered once per day Continuously for 14 days with the stimulation over the left DLPFC. Left DLPFC GABA level relative to creatine (Cr) was measured by H-MRS. Insomnia symptom was evaluated by Insomnia Severity Index (ISI). MRS and ISI were assessed among all participants before and after treatment. This study was registered in the Chinese Clinical Trial Registry (No. ChiCTR2100047255).
Results: After treatment, the ISI score in real rTMS group was markedly decreased as compared to pre-rTMS (t = -4.25, p < 0.001, Cohen's d = 0.90), whereas no significant change in ISI was observed in the group of sham rTMS. In addition, we observed a significant increase of GABA+/Cr concentration in the real rTMS group after stimulation (0.37 ± 0.11 to 0.40 ± 0.11, p = 0.039), but that of sham did not (0.38 ± 0.10 to 0.39 ± 0.11, p = 0.151). However, there was no significant association between the change of GABA+/Cr in left DLPFC and the changes of ISI scores in the two groups.
Conclusion: 1 Hz rTMS has the potential to increase GABA + level in left DLPFC of patients with chronic insomnia, and warrants further investigation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.sleep.2022.03.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Perceived financial hardship and sleep in an adult population-based cohort: The mediating role of psychosocial and lifestyle-related factors.
Sleep Health
January 2025
Unit of Population Epidemiology, Division of Primary Care, Geneva University Hospitals, Geneva, Switzerland; Department of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland; School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Background: Social inequalities in sleep have been reported, but there is less research on the mechanisms underlying this association. This study investigates the relationship between financial hardship and sleep within the general adult population, focusing on the mediating effects of psychosocial and lifestyle-related factors.
Methods: We used data from the Specchio cohort, a population-based study in Geneva, Switzerland, initiated in December 2020.
Comparing Effects of Aromatherapy with Five Herbs Essential Oils on PCPA-induced Insomnia Mice.
J Microbiol Biotechnol
November 2024
Hua An Tang Biotech Group Co., Ltd., Guangzhou 510000, P.R. China.
Delayed treatment of insomnia-related symptoms can harm physical health and increase the psychological burden. In addition to oral medications and some physical therapies, aromatherapy can help overcome some treatment-related side effects. Herein, parachlorophenylalanine (PCPA)-induced insomnia was established in Kunming (KM) mice, which were subjected to aromatherapy using five plants (, , , , and ) essential oils (EOs).
View Article and Find Full Text PDFSleep quality and cognitive functioning among Chinese older adults living in the US: a mixed-effects model analysis.
BMC Geriatr
January 2025
Institute for Health, Health Care Policy and Aging Research, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
Background: Racial and ethnic disparities in sleep quality and cognitive health are increasingly recognized, yet little is understood about their associations among Chinese older adults living in the United States. This study aims to examine the relationships between sleep health and cognitive functioning in this population, utilizing data from the Population Study of Chinese Elderly in Chicago (PINE).
Methods: This observational study utilized a two-wave panel design as part of the PINE, including 2,228 participants aged 65 years or older who self-identified as Chinese.
Restless legs syndrome without insomnia and antenatal depressive symptoms.
BMC Pregnancy Childbirth
January 2025
Department of Mental Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8654, Japan.
Background: Restless legs syndrome (RLS) with insomnia is presumed to be associated with antenatal depression. RLS without insomnia, however, has not been investigated in association with antenatal depression. We aimed to examine whether RLS without insomnia during pregnancy is associated with antenatal depressive symptoms.
View Article and Find Full Text PDFMechanisms of change in an online acceptance and commitment therapy intervention for insomnia.
Sci Rep
January 2025
Department of Psychology, University of Jyväskylä, P.O. Box 35, Jyväskylä, 40014, Finland.
Insomnia, i.e., difficulty falling asleep or staying asleep, is a common condition that is connected to many psychological and physical problems.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!