In recent years, there has been a significant transformation in the field of incoherent imaging with new possibilities of compressing three-dimensional (3D) information into a two-dimensional intensity distribution without two-beam interference (TBI). Most incoherent 3D imagers without TBI are based on scattering by a random phase mask exhibiting sharp autocorrelation and low cross-correlation along the depth axis. Consequently, during reconstruction, high lateral and axial resolutions are obtained. Scattering based-Imaging requires a wasteful photon budget and is therefore precluded in many power-sensitive applications. This study develops a proof-of-concept 3D incoherent imaging method using a rotating point spread function termed 3D Incoherent Imaging with Spiral Beams (3DISB). The rotation speed of the point spread function (PSF) with displacement and the orbital angular momentum has been theoretically analyzed. The imaging characteristics of 3DISB were compared with a direct imaging system using a diffractive lens, and the proposed system exhibited a higher focal depth than the direct imaging system. Different computational reconstruction methods such as the Lucy-Richardson algorithm (LRA), non-linear reconstruction (NLR), and the Lucy-Richardson-Rosen algorithm (LRRA) were compared. While LRRA performed better than both LRA and NLR for an ideal case, NLR performed better than both under real experimental conditions. Both single plane imaging, as well as synthetic 3D imaging, were demonstrated. We believe that the proposed approach might cause a paradigm shift in the current state-of-the-art incoherent imaging, fluorescence microscopy, and astronomical imaging.
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http://dx.doi.org/10.1186/s11671-022-03676-6 | DOI Listing |
J Biomed Opt
January 2025
The Johns Hopkins University, Department of Biomedical Engineering, Baltimore, Maryland, United States.
Significance: Laparoscopic surgery presents challenges in localizing oncological margins due to poor contrast between healthy and malignant tissues. Optical properties can uniquely identify various tissue types and disease states with high sensitivity and specificity, making it a promising tool for surgical guidance. Although spatial frequency domain imaging (SFDI) effectively measures quantitative optical properties, its deployment in laparoscopy is challenging due to the constrained imaging environment.
View Article and Find Full Text PDFMagn Reson Imaging
January 2025
Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, Beijing, China. Electronic address:
Objective: To explore the potential of Intravoxel Incoherent Motion Diffusion (IVIM) and Arterial Spin Labeling (ASL) in predicting the short-term effectiveness of post-revascularization for severe atherosclerotic renal artery stenosis.
Material And Methods: A retrospective analysis of 88 cases from October 2018 to February 2023 was conducted. Patients were divided into Responder and Non-Responder groups based on renal function outcomes at their last follow-up.
Inflamm Bowel Dis
January 2025
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Background: We previously identified circulating and MRI biomarkers associated with the surgical management of Crohn's disease (CD). Here we tested associations between these biomarkers and ileal resection inflammation and collagen content.
Methods: Fifty CD patients undergoing ileal resection were prospectively enrolled at 4 centers.
Sci Rep
January 2025
Department of Radiology, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, Turku, 20521, Finland.
To assess the utility of IVIM parameters in evaluating uterine fibroid blood flow compared to dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) derived blood flow. Sixteen premenopausal women with uterine fibroids were enrolled in this prospective study. Pelvic MRI scans were obtained for each subject, both with and without continuous intravenous infusion of oxytocin, known to decrease significantly uterine fibroid blood flow, to assess the changes in blood flow of uterine fibroids.
View Article and Find Full Text PDFQuant Imaging Med Surg
January 2025
Department of MRI, the First People's Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
Background: Accurate differentiation between benign and malignant endometrial lesions holds substantial clinical importance. This study aimed to evaluate the efficacy of various diffusion models in the preoperative diagnosis of early-stage endometrial carcinoma (EC).
Methods: A total of 72 consecutive patients with benign or malignant endometrial lesions from the First People's Hospital of Yunnan Province were prospectively enrolled between April 2021 and July 2023.
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