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Elastic mucus strands impair mucociliary clearance in cystic fibrosis pigs. | LitMetric

Elastic mucus strands impair mucociliary clearance in cystic fibrosis pigs.

Proc Natl Acad Sci U S A

Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242.

Published: March 2022

AI Article Synopsis

Article Abstract

SignificanceIn many lung diseases, increased amounts of and/or abnormal mucus impair mucociliary clearance, a key defense against inhaled and aspirated material. Submucosal glands lining cartilaginous airways secrete mucus strands that are pulled by cilia until they break free from the duct and sweep upward toward the larynx, carrying particulates. In cystic fibrosis (CF) pigs, progressive clearance of insufflated microdisks was repeatedly interrupted as microdisks abruptly recoiled. Aerosolizing a reducing agent to break disulfide bonds linking mucins ruptured mucus strands, freeing them from submucosal gland ducts and allowing cilia to propel them up the airways. These findings highlight the abnormally increased elasticity of CF mucus and suggest that agents that break disulfide bonds might have value in lung diseases with increased mucus.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9060506PMC
http://dx.doi.org/10.1073/pnas.2121731119DOI Listing

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