[Morpho- and pathogenesis of nephrosclerosis: a clinico-morphological analysis].

The authors have defined 2 phases in morphogenesis of nephrosclerosis: "nosological" and "syndrome". In the first phase the development of nephrosclerosis is determined by the peculiarities of pathogenesis of the main disease and associated with a certain structural element of the kidney (arterioles, glomerula, stroma). The second phase occurs after the formation of block of the renal blood flow at one or another structural level (arteriolar, glomerular, capillary-parenchymatous) including the hypoxic factor which determines subsequent progression of nephrosclerosis. The nosological signs of nephrosclerosis in this phase are leveled down, replaced by the signs of the syndrome of chronic renal failure. Arterial hypertension is a factor contributing to the progression of nephrosclerosis irrespective of nosological entity.