AI Article Synopsis
- * The structures of the new compounds were determined using advanced techniques like NMR and mass spectrometry, while the configuration of one compound was established through optical rotation comparisons.
- * Coniosulfide E has a unique structure and shows moderate anti-inflammatory potential, suggesting that the fungus could be a source for developing new anti-inflammatory agents.
Article Abstract
is well-known as the second-largest contributor of fungal natural products. Based on NMR guided isolation, three nitrogen-containing secondary metabolites, including two new compounds, variotin B () and coniosulfide E (), together with a known compound, unguisin A (), were isolated from the ethyl acetate (EtOAc) extract of the deep-sea fungus IV17-109. The planar structures of and were elucidated by an extensive analysis of their spectroscopic data (HRESIMS, 1D and 2D NMR). The absolute configuration of was determined by comparison of its optical rotation value with those of the synthesized analogs. Compound is a rare, naturally occurring substance with an unusual cysteinol moiety. Furthermore, showed moderate anti-inflammatory activity with an IC value of 20.0 µM. These results revealed that could produce structurally diverse nitrogenous secondary metabolites, which can be used for further studies to find anti-inflammatory leads.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948696 | PMC |
| http://dx.doi.org/10.3390/md20030217 | DOI Listing |
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