Butenolides from the Coral-Derived Fungus SCSIO41404.

Five undescribed butenolides including two pairs of enantiomers, (+)-asperteretal G (), (-)-asperteretal G (), (+)-asperteretal H (), (-)-asperteretal H (), asperteretal I (), and -hydroxybenzaldehyde derivative, ()-3-(2,3-dihydroxy-3-methylbutyl)-4-hydroxybenzaldehyde (), were isolated together with ten previously reported butenolides -, from the coral-derived fungus SCSIO41404. Enantiomers / and / were successfully purified by high performance liquid chromatography (HPLC) using a chiral column, and the enantiomers and were new natural products. Structures of the unreported compounds, including the absolute configurations, were elucidated by NMR and MS data, optical rotation, experimental and calculated electronic circular dichroism, induced circular dichroism, and X-ray crystal data. The isolated butenolides were evaluated for antibacterial, cytotoxic, and enzyme inhibitory activities. Compounds and displayed weak antibacterial activity, against (IC = 25 μg/mL) and (IC = 50 μg/mL), respectively, whereas showed weak inhibitory effect on acetylcholinesterase. Nevertheless, most of the butenolides showed inhibition against pancreatic lipase (PL) with an inhibition rate of 21.2-73.0% at a concentration of 50 μg/mL.