(1) Background: Following radical prostatectomy (RP), the absence of a demonstrable tumor on the specimen of a previously histologically proven malignancy is known as the pT0 stage. The aim of our present study is to perform a narrative review of current literature in order to determine the frequency and oncological outcomes in patients with pT0 disease. (2) Methods: A narrative review of all available literature was performed. (3) Results: The incidence of pT0 ranges between 0.07% and 1.3%. Predictors of the pT0 stage are only a single biopsy core with low-grade cancer, a cancer length not exceeding 2 mm and a high prostate volume. Biochemical recurrence ranges between 0 and 11%. (4) Conclusions: The absence of malignancy in the RP specimen despite a previous positive biopsy is a rare and unpredictable finding. Although the prognosis is considered to be excellent in most of the cases, a continued close follow-up is warranted.
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http://dx.doi.org/10.3390/curroncol29030111 | DOI Listing |
Cureus
December 2024
Family Medicine, SingHealth Polyclinics, Singapore, SGP.
Premature costochondral calcification is a rare finding occurring in young patients and is associated with metabolic and endocrinological conditions. Significant heterogeneity exists with regard to its definition and assessment. This scoping review aimed to summarize the prevalence, risk factors, etiology, evaluation, and management of patients with premature costochondral calcification.
View Article and Find Full Text PDFGlucagon-like peptide-1 agonists (GLP-1 RAs) have produced substantial weight loss effects in type 2 diabetes mellitus (T2DM) cohorts, but these effects have not been thoroughly studied in patients with obesity and without diabetes. This review aimed to analyze direct comparative studies for semaglutide versus other GLP-1 RA (liraglutide and efinopegdutide) in facilitating weight loss and evaluating adverse events in patients with obesity. A systematic search following the guidelines established by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was performed in PubMed, Embase, and Cochrane Library for direct comparative studies comparing semaglutide with other GLP-1 RA on weight loss in patients with obesity.
View Article and Find Full Text PDFArthrosc Sports Med Rehabil
December 2024
Department of Orthopedic Surgery & Rehabilitation, Loyola University Medical Center, Maywood, Illinois, U.S.A.
Purpose: To determine the incidence rate (IR) of anterior cruciate ligament (ACL) and associated musculoskeletal injuries in recreational and/or military-training obstacle course races (OCRs) and to determine whether there are any risk factors or features of OCRs impacting the rate of ACL injury in race participants.
Methods: This systematic review was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Studies were identified using the following electronic databases: PubMed, EMBASE, Cochrane, and Scopus.
Focus (Am Psychiatr Publ)
January 2025
Child and Adolescent Mental Health Service, Children's Hospital Dr. Roberto del Río, Santiago, Chile (Velasco); Public Health School, Faculty of Medicine, University of Chile, Santiago, Chile (Cruz); División of Psychiatry, University College London, London, UK (Billings, Rowe); Camden and Islington Mental Health Foundation Trust, London, UK (Jimenez).
Background: Increasing rates of mental health problems among adolescents are of concern. Teens who are most in need of mental health attention are reluctant to seek help. A better understanding of the help-seeking in this population is needed to overcome this gap.
View Article and Find Full Text PDFAnaesthesia
January 2025
Anaesthetic Department, Royal Surrey Hospital Foundation Trust, Guildford, UK.
Introduction: Peri-operative medicine is becoming increasingly relevant in the context of managing frail patients with cancer. This paper outlines how demographic shifts in populations are affecting cancer incidence and frailty rates, the relevance this holds to the management of cancer care, and the outcome measures that should be used to gauge best clinical practice to ensure patient-centred care.
Methods: A targeted literature review was conducted using the search terms 'surgical oncology', 'outcomes', 'frailty', 'quality of life' and 'end of life' from 10 to 17 June 2024.
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