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Probing Site-Selective Conjugation Chemistries for the Construction of Homogeneous Synthetic Glycodendriproteins. | LitMetric

Probing Site-Selective Conjugation Chemistries for the Construction of Homogeneous Synthetic Glycodendriproteins.

Chembiochem

Departament de Química Analítica i Química Orgànica, Facultat de Química, Universitat Rovira i Virgili, C/ Marcel⋅lí Domingo 1, 43007, Tarragona, Spain.

Published: May 2022

AI Article Synopsis

Article Abstract

Methods that site-selectively attach multivalent carbohydrate moieties to proteins can be used to generate homogeneous glycodendriproteins as synthetic functional mimics of glycoproteins. Here, we study aspects of the scope and limitations of some common bioconjugation techniques that can give access to well-defined glycodendriproteins. A diverse reactive platform was designed via use of thiol-Michael-type additions, thiol-ene reactions, and Cu(I)-mediated azide-alkyne cycloadditions from recombinant proteins containing the non-canonical amino acids dehydroalanine, homoallylglycine, homopropargylglycine, and azidohomoalanine.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322419PMC
http://dx.doi.org/10.1002/cbic.202200020DOI Listing

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