The introduction of a ring-fused segment into a BODIPY scaffold promoted a spectral bathochromic-shift and enhanced the intersystem crossing capability by a twisted structure. In this work, we designed and synthesized an upper ring-fused BODIPY with 4-dimethylaminostyryl groups (BBDP), which had excellent optical performance for photothermal-photodynamic therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d2tb00012a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tumor microenvironment-responsive and modulatory manganese-based nanoenzyme for enhanced tumor immunotherapy.
Front Pharmacol
January 2025
Department of General Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
The characteristics of the tumor microenvironment (TME) have a close and internal correlation with the effect of cancer immunotherapy, significantly affecting the progression and metastasis of cancer. The rational design of nanoenzymes that possess the ability to respond to and regulate the TME is driving a new direction in catalytic immunotherapy. In this study, we designed a multifunctional manganese (Mn)-based nanoenzyme that is responsive to acidic pH and overxpressed HO at tumor site and holds capability of modulating hypoxic and immunosuppressive TME for synergistic anti-tumor photothermal/photodynamic/immunotherapy.
View Article and Find Full Text PDFIntegrating Photothermal, Photodynamic, and Chemodynamic Therapies: The Innovative Design Based on Copper Sulfide Nanoparticles for Enhanced Tumor Therapy.
ACS Appl Bio Mater
January 2025
School of Pharmacy, Shenyang Key Laboratory of Functional Drug Carrier Materials, Shenyang Pharmaceutical University, Shenyang 110016, China.
A multifunctional nanoplatform integrating multiple therapeutic functions may be an effective strategy to realize satisfactory therapeutic efficacy in the treatment of tumors. However, there is still a certain challenge in integrating multiple therapeutic agents into a single formulation using a simple method due to variations in their properties. In this work, multifunctional CuS-ICG@PDA-FA nanoparticles (CIPF NPs) with excellent ability to produce reactive oxygen species and photothermal conversion performance are fabricated by a simple and gentle method.
View Article and Find Full Text PDFEffective One-for-All Phototheranostic Agent for Hypoxia-Tolerant NIR-II Fluorescent/PA Image-Guided Phototherapy.
Small
January 2025
Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, P. R. China.
Near-infrared (NIR)-triggered type-I photosensitizers are crucial to address the constraints of hypoxic tumor microenvironments in phototherapy; however, significant challenges remain. By selecting an electron-deficient unit, a matched energy gap in the upper-level state is instrumental in boosting the efficiency of intersystem crossing for the type-I electron transfer process. 2-Cyanothiazole, an electron acceptor, is covalently linked with N, N-diphenyl-4-(thiophen-2-yl)aniline to yield a multifunctional photosensitizer (TTNH) that exhibits intrinsic NIR absorbance and compatible T energy levels, facilitating both radiative and nonradiative transitions.
View Article and Find Full Text PDFGold nanorods coated with self-assembled silk fibroin for improving their biocompatibility and facilitating targeted photothermal-photodynamic cancer therapy.
Nanoscale
January 2025
Zhejiang Provincial Key Laboratory of Utilization and Innovation of Silkworm and Bee Resources, Institute of Applied Bioresource Research, College of Animal Science, Zhejiang University, Yuhangtang Road 866, Hangzhou, 310058 Zhejiang, P. R. China.
Gold nanorods (AuNRs) have shown great potential as photothermal agents for cancer therapy. However, the biosafety of AuNRs ordinarily synthesized using a cationic ligand assistance procedure has always been a subject of controversy, which limits their application in tumor therapy. In this study, we propose a novel strategy to enhance the biocompatibility of AuNRs by constructing a biological coating derived from silk fibroin (SF) on their surface.
View Article and Find Full Text PDFGold nanocages co-assembled with Spinacia oleracea extract combined photothermal/photodynamic therapy in 4T1 breast cancer cell line.
Biomed Mater
January 2025
Department of Biomedical Engineering, Indian Institute of Technology, Indian Institute of Technology Hyderabad, HYderabad, Telangana, 502284, INDIA.
Photothermal therapy (PTT) and photodynamic therapy (PDT) have been emerging as potential alternatives to conventional cancer treatment modalities. Gold nanoparticles, owing to their surface plasmon resonance properties, have been promising in cancer phototherapies, and extracts from potentially medicinal plants are commonly employed for the green synthesis of various nanoparticles. Some researchers also have been using chlorophyll as the photosensitizer for reactive oxygen species (ROS) generation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!