AI Article Synopsis
- Hyperlactatemia, or elevated lactate levels, is frequently observed in patients after heart transplantation, with all studied patients showing levels above 2 mmol/l.
- A study involving 143 heart transplant patients found that while nonsurvivors had higher maximum lactate levels and worse lactate clearance, these factors did not correlate with 1-year mortality.
- The minimum lactate level emerged as a significant predictor of mortality, proving more effective in assessing patient prognosis than maximum lactate or lactate clearance metrics.
Article Abstract
Hyperlactatemia is common post-heart transplantation. Lactate measurements in the first 24 h were analyzed with respect to mortality. A total of 153 consecutive cardiac transplant patients were reviewed. Recipients of organs maintained in a state of perfusion were included. A total of 143 heart recipients were included. Hyperlactatemia (>2 mmol/l) was present in all patients. Despite maximum lactate and lactate clearance being significantly higher in nonsurvivors (p = 0.002, p = 0.004), neither receiver operator curve analysis nor multivariate logistic regression showed association with 1-year mortality. In comparison, the minimum lactate was significantly associated with mortality (area under the curve 0.728 [p < 0.001]; odds ratio 1.28 [95% 1.01-162; p = 0.04]). The minimum lactate, a surrogate of persistent hyperlactatemia, was demonstrated to be superior compared with maximum lactate and lactate clearance in determining patient prognosis.
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| http://dx.doi.org/10.2217/bmm-2021-1041 | DOI Listing |
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