Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321988 | PMC |
| http://dx.doi.org/10.1111/all.15290 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Research progress and immunological insights of shrimp allergens.
Fish Shellfish Immunol
January 2025
College of Marine and Environmental Sciences, Tianjin University of Science and Technology, Tianjin, 300457, China. Electronic address:
Article Synopsis
- - Allergic diseases, particularly shrimp allergy, are significant health concerns today, with a focus on key allergens like tropomyosin and arginine kinase, and their roles in different immune response reactions, including IgE-mediated hypersensitivity and non-IgE-mediated reactions.
- - Research into cross-reactivity highlights connections between shrimp allergies and other animal allergies, leveraging bioinformatics tools to better understand allergen molecular features through methods such as homology analysis and epitope prediction.
- - Advancements in treatment and diagnosis, including immunotherapy, gene editing, and innovative detection technologies, aim to reduce allergic sensitivity and improve allergy management, offering new strategies for effective prevention and control of food allergies.
Allergenic protein-induced type I hypersensitivity models: a review.
Front Allergy
October 2024
Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, China.
Context: Type I hypersensitivity affects approximately one-third of the global population. As the pathophysiology underlying the development of type I hypersensitivity (asthma, food allergy, and anaphylactic shock, etc.) is complex and heterogeneous, animal model studies continue to be the key to identifying novel molecular pathways and providing therapeutic strategies.
View Article and Find Full Text PDFDistinct mechanisms drive divergent phenotypes in hypertrophic and dilated cardiomyopathy-associated TPM1 variants.
J Clin Invest
December 2024
Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
Heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) represent starkly diverging clinical phenotypes, yet may be caused by mutations to the same sarcomeric protein. The precise mechanisms by which point mutations within the same gene bring about phenotypic diversity remain unclear. Our objective was to develop a mechanistic explanation of diverging phenotypes in two TPM1 mutations, E62Q (HCM) and E54K (DCM).
View Article and Find Full Text PDF[Component-resolved diagnosis: enhancing precision diagnosis and clinical management of shellfish allergies].
Zhonghua Yu Fang Yi Xue Za Zhi
September 2024
Department of Clinical Laboratory of the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou 510120, China.
Shellfish, being one of the eight major food allergens, affects approximately 3% of the global population. The occurrence of shellfish allergy is not only related to the individual's immune system sensitivity but is also influenced by geographical environment, food availability, and dietary habits. Although crustaceans (such as shrimp, crab, and lobster) and mollusks (such as oysters, mussels, and squid) are collectively referred to as shellfish, they exhibit significant differences in biological evolution and the spectrum of allergenic molecules they contain, leading to various allergic reactions.
View Article and Find Full Text PDFAccurate de novo design of heterochiral protein-protein interactions.
Cell Res
December 2024
Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
Article Synopsis
- Researchers designed new D-proteins (50-65 residues) that specifically bind to natural L-proteins, which could be useful in biotechnology.
- These D-proteins showed strong binding affinity to both an artificial L-peptide and important human proteins like TrkA and IL-6, while also effectively inhibiting their signaling in cell studies.
- The study revealed a high-resolution crystal structure of the D-protein-L-peptide complex, confirming the accuracy of the design method and providing insights into the unique interactions between D-proteins and L-peptides.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!