AI Article Synopsis
- Human adenovirus (HAdV) is a significant global pathogen responsible for respiratory infections, with no specific treatments or vaccines currently available.
- Edible seaweed has gained interest for its various health benefits and has shown antiviral properties; however, research on its effects specifically against HAdV is limited.
- This study found that alginate from the seaweed had low toxicity and effectively inhibited HAdV7 at all stages of the virus's life cycle, likely through the endoplasmic reticulum stress (ERS) pathway, suggesting its potential for preventing and treating HAdV infections.
Article Abstract
Human adenovirus (HAdV) has a worldwide distribution and remains a major pathogen that leads to infections of the respiratory tract. No specific treatments or vaccines are yet available for HAdV infection. , an edible seaweed, has attracted a lot of attention for its various bioactivities. has been reported to exhibit antiviral activity. However, research studies about its anti-HAdV activity are few. In this research, we found that had low cytotoxicity and possessed anti-human adenovirus type 7 (HAdV7) activity , and the most effective ingredient was alginate. The time of addition assay demonstrated inhibitory effects that were observed in all life stages of the virus. In addition, we observed that the antiviral activity of alginate against HAdV7 infection might be closely related to the endoplasmic reticulum stress (ERS) pathway. Taken together, these results suggest that extracts have potential application in the prevention and treatment of HAdV infection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8936137 | PMC |
| http://dx.doi.org/10.3389/fcimb.2022.860559 | DOI Listing |
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