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| http://dx.doi.org/10.1111/dth.15466 | DOI Listing |
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Why drug exposure is frequently associated with T-cell mediated cutaneous hypersensitivity reactions.
Front Toxicol
September 2023
Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom.
Cutaneous hypersensitivity reactions represent the most common manifestation of drug allergy seen in the clinic, with 25% of all adverse drug reactions appearing in the skin. The severity of cutaneous eruptions can vastly differ depending on the cellular mechanisms involved from a minor, self-resolving maculopapular rash to major, life-threatening pathologies such as the T-cell mediated bullous eruptions, i.e.
View Article and Find Full Text PDFArticle Synopsis
- Physalia physalis, known as Portuguese man-of-war, is a jellyfish-like organism found in tropical and subtropical oceans, primarily causing painful but usually mild stings.
- A patient experienced increasingly severe reactions to repeated stings, including intense itching (urticaria) and an unusual blistering reaction in two separate clinic visits.
- Research into the venom's compounds and potential treatments, like oral antihistamines and Aloe vera gel, is needed to better understand and address severe reactions to P. physalis stings, particularly for individuals frequently at risk.
Bullous hemorrhagic dermatosis: A rare cutaneous reaction of heparin.
J Postgrad Med
April 2023
Department of Dermatology and STD, V.M.M.C. and Safdarjung Hospital, New Delhi, India.
Bullous hemorrhagic dermatosis is a rare cutaneous reaction of heparin, a commonly used anticoagulant. Exact etiopathogenesis remains elusive but immune related mechanisms as well as dose dependent relationship have been proposed. Clinically, it is characterized by asymptomatic, tense hemorrhagic bullae on extremities or abdomen occurring 5-21 days after initiation of therapy.
View Article and Find Full Text PDFSelf-resolving bullous pemphigoid induced by cemiplimab.
Dermatol Ther
June 2022
Section of Dermatology, Department of Health and Science (DissaL), Polyclinic Hospital San Martino, IRCCS, Università di Genova, Genoa, Italy.
"PI-less DMEK": results of Descemet's membrane endothelial keratoplasty (DMEK) without a peripheral iridotomy.
Eye (Lond)
April 2019
Department of Ophthalmology, Rabin Medical Center, Petach Tikva, Israel.
Purpose: To assess Descemet's membrane endothelial keratoplasty (DMEK) without performing a peripheral iridotomy (PI) prior to or during surgery ("PI-less DMEK").
Materials And Methods: This retrospective study included consecutive patients that underwent PI-less DMEK by a single surgeon (E.L) between February 2016 and February 2017 at the Rabin Medical Center, a Tertiary Hospital.
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