AI Article Synopsis
- Most leukemic cells have fewer class I antigen sites compared to normal blood lymphocytes, but this usually doesn't affect HLA typing results.
- Leukemic cells tend to express "non HLA" or non-classical HLA antigens, which can cause false positives during HLA typing.
- Most leukemic cells express DR antigens, while DQ and MT antigen expression varies by cell type, often showing lower DQ levels in acute leukemias compared to mature B hemopathies.
Article Abstract
The study of class I and class II antigen expression on leukemic cells brought the following conclusions: most of the leukemic cells show a slower number of class I antigenic sites than normal peripheral blood lymphocytes (PBL) but, in most cases, this does not hinder HLA typing; contrarily to normal PBL, leukemic cells seem to carry "non HLA" antigens (and/or non classical HLA antigens) which are probably responsible of the false positive reactions frequently observed at the time of HLA typing; most of the leukemic cell types express DR antigens (except those belonging to the T lineage) but DQ antigen expression (and in some cases MT antigen expression) varies depending on the cell type studied: well defined on mature B hemopathies, DQ expression is often lower than DR expression on acute leukemic cell types.
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