Iridociliary ring melanoma is an uncommon type of uveal melanoma. Clinical manifestation varies from asymptomatic cases to masquerade syndromes mimicking refractory glaucoma. Treatment options include radiotherapy and enucleation. Management of metastatic uveal melanoma remains discouraging. Novel therapies using immune checkpoint inhibitors are currently under study. We present a case of a 54-year-old Hispanic woman with progressive vision loss due to metastatic ring melanoma with anterior chamber seeding treated with pembrolizumab.

Download full-text PDF

Source
http://dx.doi.org/10.5935/0004-2749.20230046DOI Listing

Publication Analysis

Top Keywords

ring melanoma
12
iridociliary ring
8
treated pembrolizumab
8
uveal melanoma
8
melanoma
5
beneath surface
4
surface case
4
case report
4
report metastatic
4
metastatic iridociliary
4

Similar Publications

Microinvasive Retained Foreign Body Removal With the Use of a Dermoscopic Working Ring.

Dermatol Pract Concept

October 2024

Melanoma and Skin Cancer Unit, Department of Dermatology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

View Article and Find Full Text PDF

Tumor cells are decorated with aberrant glycan structures on cell surfaces. It is well known that the glycocalyx serves as a main cellular regulator, although its role in cancer is still not completely understood. Over recent decades, several non-natural monosaccharides carrying clickable groups have been introduced in melanoma cells.

View Article and Find Full Text PDF

Integrated genome and metabolome mining unveiled structure and biosynthesis of novel lipopeptides from a deep-sea Rhodococcus.

Microb Biotechnol

November 2024

Department of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Giardini del Molosiglio, Naples, Italy.

Microbial biosurfactants have garnered significant interest from industry due to their lower toxicity, biodegradability, activity at lower concentrations and higher resistance compared to synthetic surfactants. The deep-sea Rhodococcus sp. I2R has been identified as a producer of glycolipid biosurfactants, specifically succinoyl trehalolipids, which exhibit antiviral activity.

View Article and Find Full Text PDF

Aberrant Ras homologous (Rho) GTPase signalling is a major driver of cancer metastasis, and GTPase-activating proteins (GAPs), the negative regulators of RhoGTPases, are considered promising targets for suppressing metastasis, yet drug discovery efforts have remained elusive. Here, we report the identification and characterization of adhibin, a synthetic allosteric inhibitor of RhoGAP class-IX myosins that abrogates ATPase and motor function, suppressing RhoGTPase-mediated modes of cancer cell metastasis. In human and murine adenocarcinoma and melanoma cell models, including three-dimensional spheroid cultures, we reveal anti-migratory and anti-adhesive properties of adhibin that originate from local disturbances in RhoA/ROCK-regulated signalling, affecting actin-dynamics and actomyosin-based cell-contractility.

View Article and Find Full Text PDF
Article Synopsis
  • The study examined midzonal iris pigment epithelial (IPE) cysts, which are usually harmless but can be confused with ciliary body melanoma, to better understand their characteristics using ultrasound biomicroscopy (UBM).
  • Researchers reviewed 69 patient charts, finding that cysts were most common in older adults (median age 66), with a slight female majority and various cyst sizes, often located inferotemporally in the eye.
  • UBM revealed that many cases thought to have multiple cysts were actually single cysts with distinct shapes, and associated peripheral IPE cysts were found in a majority of the evaluated eyes.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!