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Regulation of Carbapenemase Gene Conjugation in Clinical Isolates. | LitMetric
The purpose of this study is to raise awareness of the hazards of carbapenemase epidemics and provide theoretical support for preventing the spread of carbapenemase-producing organisms. A total of 893 non-duplicate strains were recruited from three major local hospitals. The carbapenemase genotype of each imipenem-resistant strain was analyzed. Molecular typing and homology analysis of the main carbapenemase-producing strains reveal the transmission mode of resistance genes. Through the conjugation experiment, the potential spreading risk of carbapenemase genes was analyzed. Extended-spectrum beta-lactamase genes and replicon detection of the conjugant carrying plasmid were performed. The unannotated bacterial small non-coding RNAs (sRNAs) interacting with were predicted through a bioinformatics tool. The sRNAs overexpression and knockout strains were constructed, and the effect of sRNA on conjugation was analyzed. A total of 8 carbapenemase-producing strains were detected (0.90%, 8/893). The main carbapenemase genotype was (7 strains). Multilocus sequence typing indicated that 7 isolates belonged to ST-10, ST-101, ST-131, ST-405, ST-410, and ST-1193, ST-2562, respectively. Homologous cluster analysis revealed that the sequence types among the 7 were high diversity. The genes were successfully transferred from these isolates to EC600 by conjugation. All transconjugant cells exhibited significantly reduced susceptibility to the imipenem. IncFII was the most common conjugative plasmid type (85.7%, 6/7). Bioinformatics predicted the interaction between and . Further experiments found that the interaction between and improved the bacterial conjugation rate between MG1655 and EC600. The regulation effect of on conjugation was not affected by the replicon type and/or harboring resistance coding genotype in conjugative plasmids. Our findings emphasized the epidemiological characteristics of carbapenemase-resistant . A functional phenotype of the new sRNA was identified, and the regulation effect of on conjugation was improved.
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