Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF00367284 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Transcriptomic Shifts in Multipotent Mesenchymal Stromal Cells during Microgravity Simulation.
Dokl Biochem Biophys
January 2025
Institute of Biomedical Problems, Russian Academy of Sciences, 123007, Moscow, Russia.
One of the most obvious manifestations of the negative impact of space flight factors on the human physiology is osteopenia. With the active development of manned space flights and the increase in the duration of humans' persistence in weightlessness, there is a growing need to understand the mechanisms of changes occurring at the cellular level involved in the replenishment of bone tissue. Using the RNA sequencing method, changes in the transcriptome profile of MMSCs were studied after a 5-day simulation of the microgravity effects.
View Article and Find Full Text PDFLong-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: sex-specific epigenetic reprogramming.
Radiat Environ Biophys
January 2025
Department of Environmental Health Sciences, #820-11, Slot, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, 4301 W. Markham Str, Little Rock, AR, 72205, USA.
Most studies on the effects of galactic cosmic rays (GCR) have relied on terrestrial irradiation using spatially homogeneous dose distributions of mono-energetic beams comprised of one ion species. Here, we exposed mice to novel beams that more closely mimic GCR, namely, comprising poly-energetic ions of multiple species. Six-month-old male and female C57BL/6J mice were exposed to 0 Gy, 0.
View Article and Find Full Text PDFInterpersonal relationships as coping mechanisms during bed rest: a thematic synthesis literature review.
Front Psychol
January 2025
Institute for Kinesiology Research, Science and Research Centre Koper, Koper, Slovenia.
Bed rest (BR) studies are primarily designed to investigate the effects of weightlessness on the human body, but they are also used to study the effects of physical inactivity. For this purpose, participants are typically recruited from the general population without requiring specialized training, which contrasts with the selection process for cosmonauts. The BR study environment is often characterized as highly stressful, highlighting the importance of understanding coping mechanisms and adaptation strategies among participants, as well as the role of their daily interactions.
View Article and Find Full Text PDFExpression of MMP1, MMP3, and TIMP1 in intervertebral discs under simulated overload and microgravity conditions.
J Orthop Surg Res
January 2025
Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Capital Medical University of China, Gongti South Rd, No. 8, Beijing, 100020, China.
Objective: This study aims to investigate changes in matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) levels in the intervertebral discs of New Zealand white rabbits under simulated overload and microgravity conditions, focusing on the expression of MMP1, MMP3, and TIMP1. The findings aim to provide a theoretical foundation for preventing and delaying lumbar disc degeneration in these environments.
Methods: Overload was simulated using an animal centrifuge, and microgravity was mimicked through tail suspension.
[Prevention of periodontal inflammation in microgravity modeling].
Stomatologiia (Mosk)
January 2025
A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
The Purpose: Of the study was to assess oral microbiocenosis changes in participants of microgravity modeling in a control group and using prophylaxis in the form of a probiotic supplement with 1.0·10 CFU of strain in one lozenge and a dairy product containing not less than 1·10 CFU of s strain in one gram.
Materials And Methods: The study included 15 participants aged 25-40 years from the "Dry Immersion-2018" experiment.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!