Patients with amyotrophic lateral sclerosis (ALS) can lose all muscle-based routes of communication as motor neuron degeneration progresses, and ultimately, they may be left without any means of communication. While others have evaluated communication in people with remaining muscle control, to the best of our knowledge, it is not known whether neural-based communication remains possible in a completely locked-in state. Here, we implanted two 64 microelectrode arrays in the supplementary and primary motor cortex of a patient in a completely locked-in state with ALS. The patient modulated neural firing rates based on auditory feedback and he used this strategy to select letters one at a time to form words and phrases to communicate his needs and experiences. This case study provides evidence that brain-based volitional communication is possible even in a completely locked-in state.
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| http://dx.doi.org/10.1038/s41467-022-28859-8 | DOI Listing |
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- * The research suggests that despite paralysis, preserved cognitive processing can exist, as evidenced by the formation of sentences during communication sessions, challenging previous assumptions about complete loss of thought capabilities.
- * Emphasizing feedback and reinforcement as essential for effective communication, the study also highlights the significance of psychosocial factors and the length of immobilization in understanding barriers to communication in locked-in patients.
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