A new concept of human-machine interface to control hand prostheses based on displacements of multiple magnets implanted in the limb residual muscles, the myokinetic control interface, has been recently proposed. In previous works, magnets localization has been achieved following an optimization procedure to find an approximate solution to an analytical model. To simplify and speed up the localization problem, here we employ machine learning models, namely linear and radial basis functions artificial neural networks, which can translate measured magnetic information to desired commands for active prosthetic devices. They were developed offline and then implemented on field-programmable gate arrays using customized floating-point operators. We optimized computational precision, execution time, hardware, and energy consumption, as they are essential features in the context of wearable devices. When used to track a single magnet in a mockup of the human forearm, the proposed data-driven strategy achieved a tracking accuracy of 720 μm 95% of the time and latency of 12.07 μs. The proposed system architecture is expected to be more power-efficient compared to previous solutions. The outcomes of this work encourage further research on improving the devised methods to deal with multiple magnets simultaneously.
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http://dx.doi.org/10.1109/TBCAS.2022.3161133 | DOI Listing |
AIDS Res Ther
December 2024
Department of Neurology, Xi'an International Medical Center Hospital, xitai road, gaoxin District, Xi'an city, Shaanxi Province, China.
Background: Human immunodeficiency virus (HIV) is a retrovirus mainly infecting immune cells. Central nervous system diseases in HIV-infected patients can be caused by HIV or opportunistic infections. Neurological diseases associated with HIV have diverse manifestations and may occur in early or late stages.
View Article and Find Full Text PDFIn Vivo
December 2024
School of Physics, Mathematics and Computing, The University of Western Australia, Perth, Australia.
Background/aim: Tumors exhibit impaired blood flow and hypoxic areas, which can reduce the effectiveness of treatments. Characterizing these tumor features can inform treatment decisions, including the use of vasculature modulation therapies. Imaging provides insight into these characteristics, with techniques varying between clinical and preclinical settings.
View Article and Find Full Text PDFPsychiatry Res
December 2024
Department of Neurology, Affiliated Hospital of North Sichuan Medical College; Institute of Neurological Diseases, North Sichuan Medical College, Nanchong 637000, Sichuan, China. Electronic address:
Background: Major depressive disorder (MDD) is prevalent among older patients and is frequently associated with cognitive decline and a reduced quality of life. Non-invasive brain stimulation (NIBS) techniques show promise for treating MDD, but their comparative efficacy and safety older populations remain unclear. This study aimed to compare the efficacy and cognitive effects of various NIBS techniques in treating MDD in older patients.
View Article and Find Full Text PDFHum Brain Mapp
January 2025
Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, UK.
Disruptions to brain networks, measured using structural (sMRI), diffusion (dMRI), or functional (fMRI) MRI, have been shown in people with multiple sclerosis (PwMS), highlighting the relevance of regions in the core of the connectome but yielding mixed results depending on the studied connectivity domain. Using a multilayer network approach, we integrated these three modalities to portray an enriched representation of the brain's core-periphery organization and explore its alterations in PwMS. In this retrospective cross-sectional study, we selected PwMS and healthy controls with complete multimodal brain MRI acquisitions from 13 European centers within the MAGNIMS network.
View Article and Find Full Text PDFChem Asian J
December 2024
Guangxi Normal University, School of chemistry and pharmaceutical science, No.15, Yucai Road, 541004, Guilin, CHINA.
The anomalous expression of microRNA poses a serious threat to human life and health safety, and serves as an important biomarker for cancer detection. In this study, a novel magnetic-assisted DNA logic gate nanomachine triggered by miRNA-21 and miRNA-155 was designed based on the trans-cleavage activity of CRISPR/Cas12a activated by a split DNA activator, using only a single crRNA and signal probe, which simplified the detection procedure and complex nucleic acid amplification. The presence of target molecules, miRNA-21 and miRNA-155, can stimulate the DNA walker machine assembled on magnetic beads, which releases activator under the action of DNAzyme.
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