AI Article Synopsis
- Nanogels made from chitosan and hyaluronic acid with paramagnetic Gd chelates show promise for improving magnetic resonance bioimaging techniques.
- Researchers found that a unique Gd complex, [Gd(DOTP)], produced a significantly higher relaxivity value compared to free Gd complexes, highlighting the influence of water molecules that form strong hydrogen bonds with the complex.
- Initial imaging studies demonstrated rapid elimination of these paramagnetic complexes from the body, indicating their potential for safe and efficient use in medical imaging.
Article Abstract
Nanogels (NGs) obtained by electrostatic interactions between chitosan and hyaluronic acid and comprising paramagnetic Gd chelates are gaining increasing attention for their potential application in magnetic resonance bioimaging. Herein, the macrocyclic complexes [Gd(DOTP)], lacking metal-bound water molecules ( = 0), were confined or used as a cross-linker in this type of NG. Unlike the typical behavior of Gd complexes with = 0, a remarkable relaxivity value of 78.0 mM s was measured at 20 MHz and 298 K, nearly 20 times greater than that found for the free complex. A careful analysis of the relaxation data emphasizes the fundamental role of second sphere water molecules with strong and long-lived hydrogen bonding interactions with the complex. Finally, PEGylated derivatives of nanoparticles were used for the first magnetic resonance imaging study of this type of NG, revealing a fast renal excretion of paramagnetic complexes after their release from the NGs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985129 | PMC |
| http://dx.doi.org/10.1021/acs.inorgchem.2c00225 | DOI Listing |
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