Invited for this month's cover is the group of Anna J. McConnell and Christian Näther from Christian-Albrechts-Universität zu Kiel, Germany. The cover picture shows an amidoboronate puzzle divided into four quarters that represent four possible amidoboronates. How do these amidoboronates interconvert? The right combination of aniline (yellow circles) and catechol (grey and purple circles) pieces solves this conundrum and the amidoboronates interconvert via dynamic covalent B-N (left to right) and B-O bonds (top to bottom). More information can be found in the Research Article by Anna J. McConnell and co-workers.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cplu.202200085 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Controlling the transmembrane transport of chloride by dynamic covalent chemistry with azines.
Chem Sci
January 2025
Engineering of Molecular NanoSystems, Université libre de Bruxelles (ULB) Avenue F.D. Roosevelt 50, CP165/64 B-1050 Brussels Belgium
Stimuli-responsive transmembrane ion transport has become a prominent area of research due to its fundamental importance in cellular processes and potential therapeutic applications. Commonly used stimuli include pH, light, and reduction or oxidation agents. This paper presents the use of dynamic covalent chemistry to activate and modulate the transmembrane transport of chloride in liposomes.
View Article and Find Full Text PDFModulation of Protein-Protein Interactions with Molecular Glues in a Synthetic Condensate Platform.
J Am Chem Soc
January 2025
Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
Misregulation of protein-protein interactions (PPIs) underlies many diseases; hence, molecules that stabilize PPIs, known as molecular glues, are promising drug candidates. Identification of novel molecular glues is highly challenging among others because classical biochemical assays in dilute aqueous conditions have limitations for evaluating weak PPIs and their stabilization by molecular glues. This hampers the systematic discovery and evaluation of molecular glues.
View Article and Find Full Text PDFGelatin-Based Adhesive Hydrogels with Self-Healing, Injectable and Temperature-Triggered Detachable Properties.
Macromol Biosci
January 2025
School of Life Sciences and Health Engineering, Jiangnan University, Wuxi, Jiangsu, 214122, P. R. China.
Adhesive hydrogels are emerging as attractive functional materials for various fields, such as tissue engineering, wound healing, E-skins, etc. However, the removal of adhesive hydrogels from covered area may be painful and cause a secondary damage. In the current study, gelatin-based hydrogels are prepared by cross-linking with tannic acid and 4-formylphenyl boronic acid, through simultaneous dynamic covalent boronic ester and imine bond formations.
View Article and Find Full Text PDFO-GlcNAcylation regulates tyrosine hydroxylase serine 40 phosphorylation and L-DOPA levels.
Am J Physiol Cell Physiol
January 2025
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro.
O-GlcNAcylation is a post-translational modification characterized by the covalent attachment of a single moiety of GlcNAc on serine/threonine residues in proteins. Tyrosine hydroxylase (TH), the rate-limiting step enzyme in the catecholamine synthesis pathway and responsible for production of the dopamine precursor, L-DOPA, has its activity regulated by phosphorylation. Here, we show an inverse feedback mechanism between O-GlcNAcylation and phosphorylation of TH at serine 40 (TH pSer40).
View Article and Find Full Text PDFUncovering the naturally occurring covalent inhibitors of SARS-CoV-2 M from the Chinese medicine sappanwood and deciphering their synergistic anti-M effects.
J Ethnopharmacol
January 2025
Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, 310014. Electronic address:
Ethnopharmacological Relevance: The Chinese medicine sappanwood is primarily sourced from the dried heartwood of the medicinal plant Caesalpinia sappan Linn., which has been found with a variety of valuable properties including anti-inflammatory, anti-oxidant, and anti-viral effects. Preliminary investigations have demonstrated that sappanwood showed strong anti-SARS-CoV-2 M effects, but the key constituents responsible for SARS-CoV-2 M inhibition and their anti-M mechanisms have not been uncovered.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!