Near-infrared excitation/emission microscopy with lanthanide-based nanoparticles.

Anal Bioanal Chem

Instituto de Ciencia Molecular (ICMol), Departamento de Química Orgánica, University of Valencia, Catedrático José Beltrán, 2, 46980, Paterna, Valencia, Spain.

Published: June 2022

AI Article Synopsis

  • Near-infrared optical imaging has advantages like deeper tissue penetration and low autofluorescence, making it effective for medical applications.
  • Lanthanide-doped nanoparticles (LnNPs) are gaining popularity in optical imaging due to their unique properties that allow them to effectively use near-infrared light.
  • This review discusses the use of NaREF nanoparticles in various imaging techniques and highlights ongoing research on the properties and future potential of nanohybrid materials in optical microscopy.

Article Abstract

Near-infrared optical imaging offers some advantages over conventional imaging, such as deeper tissue penetration, low or no autofluorescence, and reduced tissue scattering. Lanthanide-doped nanoparticles (LnNPs) have become a trend in the field of photoactive nanomaterials for optical imaging due to their unique optical features and because they can use NIR light as excitation and/or emission light. This review is focused on NaREF NPs and offers an overview of the state-of-the-art investigation in their use as luminophores in optical microscopy, time-resolved imaging, and super-resolution nanoscopy based on, or applied to, LnNPs. Secondly, whenever LnNPs are combined with other nanomaterial or nanoparticle to afford nanohybrids, the characterization of their physical and chemical properties is of current interest. In this context, the latest trends in optical microscopy and their future perspectives are discussed.

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Source
http://dx.doi.org/10.1007/s00216-022-03999-4DOI Listing

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