Alzheimer's disease (AD) is the most common neurodegenerative disorder. Pathologically, the disease is characterized by the deposition of amyloid beta (Aβ) plaques and the presence of neurofibrillary tangles. These drive microglia neuroinflammation and consequent neurodegeneration. While the means to affect Aβ plaque accumulation pharmacologically was achieved, how it affects disease outcomes remains uncertain. Cerium oxide (CeO) reduces Aβ plaques, oxidative stress, inflammation, and AD signs and symptoms. In particular, CeO nanoparticles (CeONPs) induce free-radical-scavenging and cell protective intracellular signaling. This can ameliorate the pathobiology of an AD-affected brain. To investigate whether CeONPs affect microglia neurotoxic responses, a novel formulation of europium-doped CeONPs (EuCeONPs) was synthesized. We then tested EuCeONPs for its ability to generate cellular immune homeostasis in AD models. EuCeONPs attenuated microglia BV2 inflammatory activities after Aβ exposure by increasing the cells' phagocytic and Aβ degradation activities. These were associated with increases in the expression of the CD36 scavenger receptor. EuCeONPs facilitated Aβ endolysosomal trafficking and abrogated microglial inflammatory responses. We posit that EuCeONPs may be developed as an AD immunomodulator.
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http://dx.doi.org/10.1021/acschemneuro.1c00847 | DOI Listing |
J Agric Food Chem
January 2025
Institute of Environmental Processes and Pollution Control, and School of Environment and Ecology, Jiangnan University, Wuxi 214122, China.
The interplay between root exudates and rhizobacteria is essential for enhancing agricultural productivity. Herein, the impacts of cerium dioxide nanomaterials (CeO NMs) on these interactions in soybean plants were investigated. Following 3-5 weeks of exposure to 5 mg·kg CeO NMs, the composition of root exudates changed over time, with isoflavone levels increasing by 6.
View Article and Find Full Text PDFMicrosc Res Tech
January 2025
Department of Restorative and Prosthetic Dental Sciences, College of Dentistry, Dar Al Uloom University, Riyadh, Saudi Arabia.
Effect of different root canal irrigation regimes microbubble emulsion (MBE) via riboflavin photosensitizer (RFP), cerium oxide (CeO) nanoparticles (NPs), and Nd: YAP laser on antibacterial efficiency, microhardness (MH), smear layer (SL) removal efficacy, and push-out bond strength (PBS) of AH plus sealer to canal dentin. Sixty single-rooted teeth were selected, disinfected, and categorized into four groups based on the type of disinfection. Following disinfection, a pair of samples were randomly selected and visualized under scanning electron microscope (SEM) for SL evaluation.
View Article and Find Full Text PDFFront Pharmacol
January 2025
The Sixth Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, The Fifth Affiliated Hospital, Guangzhou, China.
Myocardial infarction (MI) is a leading cause of morbidity and mortality worldwide, and mitigating oxidative stress is crucial in managing MI. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a critical role in combating oxidative stress and facilitating cardiac remodeling post-MI. Here, we engineered Cerium oxide (CeO) nanoparticle-guided assemblies of ceria/Nrf2 nanocomposites to deliver Nrf2 plasmids.
View Article and Find Full Text PDFRSC Adv
January 2025
State Key Laboratory of Solidification Processing, Center for Nano Energy Materials, School of Materials Science and Engineering, Northwestern Polytechnical University (NPU), Shaanxi Joint Laboratory of Graphene Xi'an 710072 China
The oxidative dehydrogenation of propane with CO (CO-ODP) is a green industrial process for producing propene. Cerium oxide-supported platinum-based (Pt/CeO) catalysts exhibit remarkable reactivity toward propane and CO due to the unique delicate balance of C-H and C[double bond, length as m-dash]O bond activation. However, the simultaneous activation and cleavage of C-H, C-C, and C-O bonds on Pt/CeO-based catalysts may substantially impede the selective activation of C-H bonds during the CO-ODP process.
View Article and Find Full Text PDFMolecules
January 2025
Faculty of Chemistry, Jagiellonian University in Krakow, Gronostajowa 2, 30-387 Krakow, Poland.
The removal of soot particles via high-performance catalysts is a critical area of research due to the growing concern regarding air pollution. Among various potential catalysts suitable for soot oxidation, cerium oxide-based materials have shown considerable promise. In this study, CeO samples obtained using a range of preparation methods (including hydrothermal synthesis (HT), sonochemical synthesis (SC), and hard template synthesis (TS)) were tested in soot combustion.
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