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Metabolomics and Biochemical Benefits of Multivitamin and Multimineral Supplementation in Healthy Individuals: A Pilot Study.
Foods
July 2024
Department of Medicine, Faculty of Medicine, University Complutense, 28040 Madrid, Spain.
Article Synopsis
- Scientific research on vitamin and mineral supplementation in healthy people is limited, but a study involving 30 participants investigated the effects of daily multivitamin and multimineral doses for 30 days.
- Metabolomic analyses showed a decrease in homocysteine levels and an increase in vitamin B6-related metabolites, indicating reduced oxidative stress and improved energy metabolism.
- The findings suggest that these supplements can positively influence nutritional balance and overall adult health, particularly concerning oxidative stress and metabolic functions.
[Influence of the rat diet enrichment with oat β-gucans on the assimilation of B group vitamins, mineral elements and lipid metabolism].
Vopr Pitan
April 2024
Siberian State Medical University, Ministry of Health of the Russian Federation, 634050, Tomsk, Russian Federation.
Article Synopsis
- The study aimed to investigate how oat bran rich in β-glucans affects the absorption of vitamins and minerals, particularly in rats with deficiencies in vitamins D, B group, and trace elements like iron, copper, and zinc.
- After a period of 23 days inducing micronutrient deficiencies, rats were given a semi-synthetic diet supplemented with missing micronutrients for 7 days, with some groups also receiving β-glucans.
- Results showed that replenishing vitamins B1, B2, and B6 eliminated deficiencies, while β-glucans enhanced iron absorption, evidenced by increased plasma iron levels and decreased urinary iron excretion.
Vitamin B: a scoping review for Nordic Nutrition Recommendations 2023.
Food Nutr Res
December 2023
Department of Clinical Science, University of Bergen, Bergen, Norway.
Pyridoxal 5´-phosphate (PLP) is the main form of vitamin B in animal tissue and functions as a coenzyme for more than 160 different enzymatic reactions in the metabolism of amino acids, carbohydrates, lipids, and neurotransmitters. Estimated dietary intake of vitamin B and plasma PLP values differ a lot between studies, something which may be due to variable use of supplements, variations in dietary assessment and analytical methods. These factors make it difficult to achieve precise data for setting a correct recommended intake of vitamin B.
View Article and Find Full Text PDFPLP-Dependent Enzyme Methionine γ-Lyase: Insights into the Michaelis Complex from Molecular Dynamics and Free Energy Simulations.
Biochemistry
September 2023
Laboratoire de Biologie Structurale de la Cellule (CNRS UMR7654), Ecole Polytechnique, Palaiseau 91128, France.
Methionine γ-lyase (MGL) breaks down methionine, with the help of its cofactor pyridoxal-5'-phosphate (PLP), or vitamin B6. Methionine depletion is damaging for cancer cells but not normal cells, so MGL is of interest as a therapeutic protein. To increase our understanding and help engineer improved activity, we focused on the reactive, Michaelis complex between MGL, covalently bound PLP, and substrate Met.
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