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Correlation Between Components of Malnutrition Diagnosed by Global Leadership Initiative on Malnutrition Criteria and the Clinical Outcomes in Gastric Cancer Patients: A Propensity Score Matching Analysis. | LitMetric

AI Article Synopsis

  • Malnutrition is a significant risk factor impacting the clinical outcomes of gastric cancer (GC) patients, and the study aimed to assess the relationship between GLIM diagnostic criteria components and these outcomes.
  • An analysis of 1,188 GC patients showed that high weight loss (WL) and low skeletal muscle index (SMI) were related to worse survival rates and higher postoperative complications, while low body mass index (BMI) did not significantly affect outcomes.
  • The findings emphasize the importance of monitoring weight loss and muscle index in GC patients to better predict and manage their clinical prognosis.

Article Abstract

Objective: Malnutrition is recognized as a risk factor for poor outcome in patients with gastric cancer (GC). In 2018, the Global Leadership Initiative on Malnutrition (GLIM) published standardized criteria for the diagnosis of malnutrition. Our aim was to investigate whether any of the components of the GLIM diagnostic criteria were related to worse clinical outcomes in patients with GC.

Methods: This study analyzed patients with GC who underwent radical gastrectomy in our hospital between 2014 and 2019. A preoperative nutritional assessment was performed for each patient. Matching was based on the presence of three GLIM components: high weight loss (WL), low body mass index (BMI), and low skeletal muscle index (SMI).

Results: The analysis included 1,188 patients, including 241 (20.3%) with high WL, 156 (13.1%) with low BMI, and 355 (29.9%) with low SMI. Before matching, patients who met the GLIM component criteria were mostly associated with older age, low nutritional reserves, and late tumor progression. After matching, the clinical characteristics of the three cohorts were balanced. In the matched queue, the survival prognosis of the high WL group was worse than that of the non-WL group, and the postoperative complication rate was higher in the low SMI group than in the normal SMI group (P <0.05). In addition, the clinical outcomes in the low and normal BMI groups were similar (P >0.05).

Conclusion: Of the GLIM criteria, high WL and low SMI may be associated with poor clinical outcomes in patients with GC, while a low BMI may not be associated with outcome.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927073PMC
http://dx.doi.org/10.3389/fonc.2022.851091DOI Listing

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