Ovarian cancer (OC) is the most lethal gynecologic cancer. Many studies have reported that RIPK4 (receptor interacting serine/threonine kinase 4) displayed a dysregulated level in many types of tumors. However, its expressions and functions in OC were rarely reported. The levels of RIPK4 were detected in OC and nontumor specimens using TCGA and GEO datasets. The prognostic values of RIPK4 in patients were determined using Kaplan-Meier methods and Kaplan-Meier assays. GO assays and KEGG pathway assays were carried out for functional enrichments. CIBERSORT was applied for estimating the fractions of immune cell types. Finally, RIPK4 was validated in pan-cancer. In this study, our group found that RIPK4 exhibited a higher level of RIPK4 in OC specimens than nontumor specimens. Survival studies revealed that patients with high RIPK4 expressions showed a shorter overall survival than those with low RIPK4 expression. Multivariate assays further confirmed that RIPK4 expression was an independent prognostic element for OC. KEGG pathway analysis displayed that the dysregulated genes in specimens with high RIPK4 expressions were enriched in focal adhesion, proteoglycans in cancer, central carbon metabolism in cancer, and insulin secretion. Correlation analyses showed that several TICs were positively correlated with RIPK4 expression. The pan-cancer validation results showed that RIPK4 was associated with survival in five tumors. Overall, our findings suggested RIPK4 as a prognostic marker in OC.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926548 | PMC |
| http://dx.doi.org/10.1155/2022/7599098 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
RIPK4 Downregulation Reduces ABCG2 Expression, Increasing BRAF-Mutated Melanoma Cell Susceptibility to Cisplatin- and Doxorubicin-Induced Apoptosis.
Biomolecules
December 2024
Department of Biophysics and Cancer Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa Street 7, 30-387 Krakow, Poland.
Melanoma cells remain resistant to chemotherapy with cisplatin (CisPt) and doxorubicin (DOX). The abnormal expression of Receptor-Interacting Protein Kinase 4 (RIPK4) in certain melanomas contributes to tumour growth through the NFκB and Wnt/β-catenin signalling pathways, which are known to regulate chemoresistance and recurrence. Despite this, the role of RIPK4 in response to chemotherapeutics in melanoma has not been reported.
View Article and Find Full Text PDFPlasma genome-wide mendelian randomization identifies potentially causal genes in idiopathic pulmonary fibrosis.
Respir Res
October 2024
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, 277#, Yanta West Road, Xi'an, Shaanxi Province, 710061, China.
Background: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease with a very poor prognosis. Existing drugs for the treatment of IPF are still insufficient. Therefore, there is still a need to explore new drug targets for preventing and treating IPF.
View Article and Find Full Text PDFRIPK4 promotes oxidative stress and ferroptotic death through the downregulation of ACSM1.
Proc Natl Acad Sci U S A
October 2024
Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
One of the most critical axes for cell fate determination is how cells respond to excessive reactive oxygen species (ROS)-oxidative stress. Extensive lipid peroxidation commits cells to death via a distinct cell death paradigm termed ferroptosis. However, the molecular mechanism regulating cellular fates to distinct ROS remains incompletely understood.
View Article and Find Full Text PDFSystematic Druggable Genome-Wide Mendelian Randomization Identifies Therapeutic Targets for Functional Outcome After Ischemic Stroke.
J Am Heart Assoc
August 2024
Department of Neurology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Article Synopsis
- * The study utilized genetic data to analyze over 2600 druggable genes, identifying 16 genes linked to improved functional outcomes, with further support from analysis techniques like Mendelian randomization and colocalization.
- * Four key candidate genes were pinpointed as potential therapeutic targets to enhance recovery after ischemic stroke, although more research is needed to understand their mechanisms and ensure safety.
Exploring the prognostic significance of arm-level copy number alterations in triple-negative breast cancer.
Oncogene
June 2024
Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, Canada.
Article Synopsis
- Somatic copy number alterations (SCNAs), especially arm-level SCNAs, are linked to cancer growth and resistance to treatment, but their role in triple-negative breast cancer (TNBC) is not well understood.
- In this study, researchers found that certain arm-level SCNAs, like gains at 21q and 7p, are connected to poorer survival rates in TNBC patients, with the gene RIPK4 on 21q being particularly significant.
- Targeting RIPK4 in experiments showed promise, as it reduced tumor growth and improved survival by enhancing immune cell infiltration, suggesting RIPK4 could be a key factor in TNBC progression and its ability to spread.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!