AI Article Synopsis
- Adhesive hydrogels are being explored as a solution for treating gastric perforations, which are life-threatening and challenging to manage with current surgical techniques.
- The study presents a new hydrogel made from a combination of gelatin and poly-N-[Tris(hydroxymethyl)methyl]acrylamide, designed for easy application and effective sealing of gastric defects.
- Tests in a mouse model demonstrate that this hydrogel not only seals perforations but also aids in the regeneration of stomach lining, highlighting its potential as a valuable treatment option.
Article Abstract
Adhesive hydrogels have been recently proposed as a potential option to seal and treat gastric perforation (GP) which causes high mortality despite advancements in surgical treatments. However, to be effective, the hydrogels must have sufficient tissue adhesiveness, tough mechanical property, tunable biodegradability and ideally are easy to apply and form. Herein, we report an adhesive and resilient hydrogel for the sealing and treatment of gastric perforation. The hydrogel consists of a bioactive, transglutaminase (TG)-crosslinked gelatin network and a dynamic, borate-crosslinked poly-N-[Tris(hydroxymethyl)methyl]acrylamide (PTH) network. The hydrogel can be formed , facilitating easy delivery to the GP and allowing for precise sealing of the defects. experiments, using a perforated stomach mouse model, shows that the adhesive hydrogel plug effectively seals GP defects and promotes gastric mucosa regeneration. Overall, this hydrogel represents a promising biomaterial for GP treatment.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892218 | PMC |
| http://dx.doi.org/10.1016/j.bioactmat.2021.11.038 | DOI Listing |
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