AI Article Synopsis
- A study evaluated the effectiveness and safety of reirradiation in 17 patients with rare head and neck tumors, focusing on locations like ears, salivary glands, and orbits.* -
- The median survival time after reirradiation was 12.6 months, with one- and two-year survival rates of 53.1% and 44.3%, and local control rates of 42.4% and 31.8% at the same intervals.* -
- While some patients experienced significant side effects (grade 3 toxicity), no severe complications (grade ≥4) were recorded, indicating that reirradiation is a viable option for these tumors with manageable risks.*
Article Abstract
We analyzed the efficacy and toxicity following reirradiation for locoregional recurrence of rare head and neck tumors. We retrospectively analyzed 17 patients who had received reirradiation for rare head and neck tumors. Primary tumor sites included nine ears (auditory organ), four salivary glands, and four orbits. The median follow-up time was 13.2 months for surviving patients. The median survival time was 12.6 months with one- and two-year survival rates of 53.1% and 44.3%, respectively. Nine out of 17 patients experienced local failure. The one- and two-year local control rates were 42.4% and 31.8%, respectively. The median survival times were 12.6, 5.3, and 11.0 months for orbit, auditory organ, and salivary glands, respectively. Three patients experienced grade 3 toxicity, including meningitis, brain necrosis, and facial nerve disorders. No grade ≥4 toxicities were observed. Reirradiation of rare head and neck tumors is feasible, with acceptable toxicity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920751 | PMC |
| http://dx.doi.org/10.7759/cureus.22727 | DOI Listing |
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