Heterogeneous multi-attribute case retrieval is a crucial step in generating emergency alternatives during the course of emergency decision making (EDM) by referring to historical cases. This paper develops a heterogeneous multi-attribute case retrieval method for EDM that considers five attribute formats: crisp numbers, interval numbers, intuitionistic fuzzy numbers, single-valued neutrosophic numbers (SvNNs), and interval-valued neutrosophic numbers (IvNNs). First, we propose a similarity measurement of IvNNs and calculate the attribute similarities for the five attribute formats. The attribute weights are established using an optimal model. Next, the case similarities are calculated and the set of the similar historical cases is constructed. Furthermore, the evaluated information based on heterogeneous multi-attribute from similar historical cases is provided, and the calculation method for the evaluation of utility based on TODIM (an acronym for interactive and multi-criteria decision-making in Portugese) is proposed. The most suitable historical case is determined based on the case similarity and the evaluated utility. From this, the emergency alternative is generated. Finally, we demonstrate the efficacy of the proposed method with a case study and conduct comparisons against the performance of existing methods to assess the validity and superiority of the proposed method.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916794 | PMC |
http://dx.doi.org/10.1007/s10489-022-03240-w | DOI Listing |
AAPS J
November 2024
Global Vaccines and Biologics Commercialization, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania, 19486, USA.
Biotherapeutics are subject to inherent heterogeneity due to the complex biomanufacturing processes. Numerous analytical techniques have been employed to identify, characterize, and monitor critical quality attributes (CQAs) to ensure product safety, and efficacy. Mass spectrometry (MS)-based multi-attribute method (MAM) has become increasingly popular in biopharmaceutical industry due to its potential to replace multiple traditional analytical methods.
View Article and Find Full Text PDFJ Pharm Biomed Anal
January 2025
National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-9501, Japan.
The multi-attribute method (MAM) has attracted increased attention as an alternative strategy for evaluating structural heterogeneity using conventional separation techniques such as ion-exchange chromatography and capillary electrophoresis of therapeutic monoclonal antibodies (mAbs). One of the remaining challenges for the practical use of the MAM is reliable and robust continuous monitoring. In this study, we successfully established an automated sample preparation system as a solution to this issue.
View Article and Find Full Text PDFAnal Bioanal Chem
October 2024
Genentech Research and Early Development, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
In recent years, the use of lipid nanoparticles (LNPs) for delivery of messenger RNA (mRNA)-based therapies has gained substantial attention in the field of drug development. In such an application, multiple LNP attributes have to be carefully characterized to ensure product safety and quality, whereas accurate and efficient characterization of these complex mRNA-LNP formulations remains a challenging endeavor. Here, we present the development and application of an online separation and characterization platform designed for the isolation and in-depth analysis of mRNAs and mRNA-loaded LNPs.
View Article and Find Full Text PDFAnal Biochem
October 2024
School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Dublin, 4, D04 V1W8, Ireland; National Institute for Bioprocessing Research & Training, Fosters Avenue, Mount Merrion, Blackrock, A94 X099, Co. Dublin, Ireland. Electronic address:
Over the past few years, the implementation of mass spectrometry (MS) in QC laboratories has become a more common occurrence. The multi-attribute method (MAM), and emerging intact multi-attribute method (iMAM), are powerful analytical tools utilising liquid chromatography-mass spectrometry (LC-MS) methods that enable the monitoring of critical quality attributes (CQAs) in biotherapeutic proteins in compliant settings. Both MAM and iMAM are intended to replace or supplement several conventional assays with a single LC-MS method utilising MS data in combination with robust, semi-automated data processing workflows.
View Article and Find Full Text PDFJ Chromatogr A
July 2024
RIC group, President Kennedypark 6, 8500 Kortrijk, Belgium; Separation Science Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281-S4, 9000 Ghent, Belgium. Electronic address:
Monoclonal antibodies (mAbs) are large and highly heterogeneous species typically characterized using a plethora of analytical methodologies. There is a trend within the biopharmaceutical industry to combine several of these methods in one analytical platform to simultaneously assess multiple structural attributes. Here, a protein analyzer for the fully automated middle-up and bottom-up liquid chromatography-mass spectrometry (LC-MS) analysis of charge, size and hydrophobic variants is described.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!