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Synthetic linear glycopolymers and their biological applications. | LitMetric

Synthetic linear glycopolymers and their biological applications.

J Carbohydr Chem

Department of Chemistry, Michigan StateUniversity, East Lansing, MI, USA.

Published: May 2021

AI Article Synopsis

Article Abstract

As typical affinities of carbohydrates with their receptors are modest, polymers of carbohydrates (glycopolymers) are exciting tools to probe the multifaceted biological activities of glycans. In this review, the linear glycopolymers and the multivalency effects are first introduced. This is followed by discussions of methods to synthesize these polymers. Subsequently, the interactions of glycopolymers with plant lectins and viral/bacterial carbohydrate binding proteins are discussed. In addition, applications of the glycopolymers in facilitating glycan microarray studies, mimicking cell surface glycans, modulation of the immune system, cryoprotection of protein, and electron-beam lithography are presented to stimulate further development of this fascinating technology.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932951PMC
http://dx.doi.org/10.1080/07328303.2021.1928156DOI Listing

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