Background: Coronary artery calcium (CAC) is an independent risk factor for major adverse cardiovascular events; however, its impact on coronavirus disease 2019 (COVID-19) mortality remains unclear, especially in patients without known atheromatous disease.
Aims: To evaluate the association between CAC visual score and 6-month mortality in patients without history of atheromatous disease hospitalized with COVID-19 pneumonia.
Methods: A single-centre observational cohort study was conducted, involving 293 consecutive patients with COVID-19 in Paris, France, between 13 March and 30 April 2020, with a 6-month follow-up. Patients with a history of ischaemic stroke or coronary or peripheral artery disease were excluded. The primary outcome was all-cause mortality at 6 months according to CAC score, which was assessed by analysing images obtained after the first routine non-electrocardiogram-gated computed tomography scan performed to detect COVID-19 pneumonia.
Results: A total of 251 patients (mean age 64.8±16.7 years) were included in the analysis. Fifty-one patients (20.3%) died within 6 months. The mortality rate increased with the magnitude of calcifications, and was 10/101 (9.9%), 15/66 (22.7%), 10/34 (29.4%) and 16/50 (32.0%) for the no CAC, mild CAC, moderate CAC and heavy CAC groups, respectively (p=0.004). Compared with the no calcification group, adjusted risk of death increased progressively with CAC: hazard ratio (HR) 2.37 (95% confidence interval [CI] 1.06-5.27), HR 3.1 (95% CI 1.29-7.45) and HR 4.02 (95% CI 1.82-8.88) in the mild, moderate and heavy CAC groups, respectively.
Conclusions: Non-electrocardiogram-gated computed tomography during the initial pulmonary assessment of patients with COVID-19 without atherosclerotic cardiovascular disease showed a high prevalence of mild, moderate and heavy CAC. CAC score was related to 6-month mortality, independent of conventional cardiovascular risk factors. These results highlight the importance of CAC scoring for patients hospitalized with COVID-19, and calls for attention to patients with high CAC.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895715 | PMC |
| http://dx.doi.org/10.1016/j.acvd.2022.02.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Waste cotton-based activated carbon with excellent adsorption performance towards dyes and antibiotics.
Chemosphere
March 2025
School of Materials Science and Engineering, Sichuan University, Chengdu, 610065, People's Republic of China. Electronic address:
A novel adsorbent is prepared from waste cotton fiber by a simple pyrolysis-activation process, and it can efficiently adsorb many kinds of organic pollutants (cationic/anionic dyes and antibiotics etc.). The obtained cotton-based activated carbon (CAC) with large specific surface area (3709 m g) and suitable pore structure provide abundant active sites and fast channels for the adsorption of pollutant molecules.
View Article and Find Full Text PDFRole of coronary artery calcification detection in tailoring patient care, personalized risk assessment, and prevention of future cardiac events.
Curr Opin Cardiol
March 2025
Ciccarone Center for the Prevention of Cardiovascular Disease, John Hopkins Hospital, Baltimore, Maryland, USA.
Purpose Of Review: We review the utility of coronary artery calcium (CAC) scoring in personalized risk assessment and initiation of cardiovascular disease risk modifying therapy.
Recent Findings: Many populations - including South Asians, patients with cancer, patients with human immunodeficiency virus (HIV), younger patients, and elderly patients - were not included during the conception of the current risk stratification tools. CAC scoring may allow clinicians to risk-stratify these individuals and help initiate preventive therapy in higher risk populations.
Redirecting immune signaling with cytokine adaptors.
Nat Commun
March 2025
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA, 94305, USA.
Cytokines are signaling molecules that coordinate complex immune processes and are frequently dysregulated in disease. While cytokine blockade has become a common therapeutic modality, cytokine agonism has had limited utility due to the widespread expression of cytokine receptors with pleiotropic effects. To overcome this limitation, we devise an approach to engineer molecular switches, termed cytokine adaptors, that transform one cytokine signal into an alternative signal with a different functional output.
View Article and Find Full Text PDFAssociations of HLA-DRB1 shared epitope alleles with cardiovascular disease and events in a multi-ethnic community-living population: The multi-ethnic study of atherosclerosis (MESA).
Hum Immunol
March 2025
Department of Orthopaedic Surgery, University of California, San Diego, United States. Electronic address:
Objective: Rheumatoid arthritis (RA) has been considered an independent risk factor for cardiovascular disease (CVD), where RA and CVD later manifest following genetic predisposition and an extended preclinical phase.TheHLA-DRB1Shared Epitope (SE)allelespredispose for RA andare associated withhigherrisk of CV mortality in RA patients, but have not been evaluated in a community-living population.Thus, we evaluated whetherHLA-DRB1 (SE) alleleswereassociated with subclinical CVD, CV events, and mortality in the Multi-Ethnic Study of Atherosclerosis (MESA).
View Article and Find Full Text PDFIn the 55th meeting of the Codex Committee on Pesticide Residues (CCPR meeting) held in June 2024 and the subsequent 47th meeting of the Codex Alimentarius Commission (CAC) (November 2024), in total 111 Codex MRLs (CXLs) for 16 active substances (a.s.) were revoked.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!