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Reform of economic evaluation of medicines in Spain: proposals from the Advisory Committee for Pharmaceutical Financing.
Gac Sanit
January 2025
Pharmacy Service, Clínica Universidad de Navarra, Pamplona, Spain; Advisory Committee on the Financing of Pharmaceutical (CAPF), Spain.
This paper describes the reforms recommended by the Advisory Committee on the Financing of Pharmaceuticals (CAPF) for the National Health System (NHS) of Spain from 2019 to 2024 for the drug pricing and reimbursement process, to integrate economic evaluations and improve efficiency and sustainability. The CAPF has proposed a three-phase reform of the economic evaluation (EE) and budget impact analysis (BIA) processes. The first phase involves the mandatory submission of EE and BIA by applicants for new drugs.
View Article and Find Full Text PDFCollagen Nanofiber-Lignin Composite Sponges with Adjustable Hierarchical Pore Structure for Efficient Low-Frequency Sound Absorption.
Adv Sci (Weinh)
January 2025
Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Current sound-absorbing materials, reliant on nonrenewable resources, pose sustainability and disposal challenges. This study introduces a novel collagen-lignin sponge (CLS), a renewable biomass-based material that combines collagen's acoustic properties with lignin's structural benefits. CLSs demonstrate high porosity (>0.
View Article and Find Full Text PDFIntegrating intuitionistic fuzzy and MCDM methods for sustainable energy management in smart factories.
PLoS One
January 2025
Department of Business Administration, College of Business Administration, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Improving energy efficiency is crucial for smart factories that want to meet sustainability goals and operational excellence. This study introduces a novel decision-making framework to optimize energy efficiency in smart manufacturing environments, integrating Intuitionistic Fuzzy Sets (IFS) with Multi-Criteria Decision-Making (MCDM) techniques. The proposed approach addresses key challenges, including reducing carbon footprints, managing operating costs, and adhering to stringent environmental standards.
View Article and Find Full Text PDFHigh-sensitivity and stability electrochemical sensors for chlorogenic acid detection based on optimally engineered nanomaterials.
Analyst
January 2025
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225009, China.
Developing cost-effective and efficient analytical methods is essential for detecting chlorogenic acid (CGA), as excessive consumption of CGA, despite its significant antioxidant, anticancer, and anti-inflammatory properties, can cause serious health problems. The remarkable progress and adjustable features of nanomaterials have significantly improved the analytical capabilities of electrochemical sensors for CGA. This review examines the use of optimally engineered nanomaterials in CGA electrochemical sensors, emphasizing the design and modification strategies of various nanomaterials.
View Article and Find Full Text PDFCoupling-Induced Dynamic Off-Centering of Cu Drives High Thermoelectric Performance in TlCuS.
J Am Chem Soc
January 2025
New Chemistry Unit, International Centre for Materials Science and School of Advanced Materials, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, Jakkur P.O. 560064, India.
Seeking new and efficient thermoelectric materials requires a detailed comprehension of chemical bonding and structure in solids at microscopic levels, which dictates their intriguing physical and chemical properties. Herein, we investigate the influence of local structural distortion on the thermoelectric properties of TlCuS, a layered metal sulfide featuring edge-shared Cu-S tetrahedra within CuS layers. While powder X-ray diffraction suggests average crystallographic symmetry with no distortion in CuS tetrahedra, the synchrotron X-ray pair distribution function experiment exposes concealed local symmetry breaking, with dynamic off-centering distortions of the CuS tetrahedra.
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