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Highly accurate DNA-based detection and treatment results of MET exon 14 skipping mutations in lung cancer.
Lung Cancer
February 2020
Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands. Electronic address:
Objectives: The oncogenic MET exon 14 skipping mutation (METex14del) is described to drive 1.3 %-5.7 % of non-small-cell lung cancer (NSCLC) and multiple studies with cMET inhibitors show promising clinical responses.
View Article and Find Full Text PDFTestosterone, 5 alpha-dihydrotestosterone and cortisol in men with and without alcohol-related aggression.
J Stud Alcohol
September 2002
Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland.
Objective: The present investigation was designed to study steroid hormones, alcohol and aggression interactions in men with a history of alcohol-related aggression (AGG+) and in a cross-sectional control population (AGG-).
Method: AGG+ (n = 40) and AGG- (n = 44) male volunteers completed the Buss-Perry Aggression Questionnaire and the revised Michigan Alcoholism Screening Test (MAST), after which plasma-free and total testosterone, 5alpha-dihydrotestosterone (DHT) and cortisol were determined.
Results: The AGG+ men displayed significantly (p < .
Quantification of sugars and organic acids in hygroscopic pharmaceutical herbal dry extracts.
J Chromatogr A
August 2002
Department of Pharmaceutical Technology, Eberhard-Karls-University Tübingen, Germany.
Three chromatographic methods have been employed for the determination of hydrophilic compounds, namely carbohydrates and organic acids in herbal dry extracts of Eschscholtzia californica Cham. The hydrophilic compounds were separated from the other components of the dry extracts by solid-phase extraction methods, which were optimised with respect to recovery rates. Carbohydrates were quantified using high-performance anion-exchange chromatography with pulsed amperometric detection.
View Article and Find Full Text PDFThis study examined the links among ego development and the ethics of care and justice in 144 Norwegian men and women, 15 to 48 years old, taking into consideration age, sex, education, and verbal intelligence. As expected, the relationship between Loevinger's model of ego development and care-based moral reasoning as measured with Skoe's Ethic of Care Interview (ECI) was significantly stronger than the one between ego development and justice as measured with Rest's Defining Issues Test (DIT). Both ethics correlated significantly with verbal ability.
View Article and Find Full Text PDFPreliminary examination of contaminant loadings in farmed salmon, wild salmon and commercial salmon feed.
Chemosphere
February 2002
International EcoGen Inc, North Vancouver, BC, Canada.
This pilot study examined five commercial salmon feeds, four farmed salmon (one Atlantic, three chinooks) and four wild salmon (one chinook, one chum, two sockeyes) from the Pacific Coast for PCBs (112 congeners), polybrominated diphenylethers (PBDEs - 41 congeners), 25 organochlorine pesticides (OPs), 20 polycyclic aromatic hydrocarbons (PAHs), and methyl and inorganic mercury. The farmed salmon showed consistently higher levels of PCBs, PBDEs, OPs (except toxaphene) than the wild salmon. The mean concentrations in pg/g were 51,216 vs 5302 for total PCBs; 2668 vs 178 for total PBDEs; 41,796 vs 12,164 for total OPs (except toxaphene).
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