A Ti/Cr cooperative catalyst isomerizes aziridines to allyl amines under mild conditions. The reaction tolerates a broad range of aziridines with various nitrogen substituents. The titanium catalyst is most successful in opening 1,2-disubstituted aziridines, forming radical intermediates in a highly regioselective manner. The chromium catalyst appears to abstract an H from these radical intermediates and then return the H to the titanium system in the form of an H and an electron. The reaction is complementary to previous reports on the isomerization of aziridines to allyl amines.
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