We have conducted fully relativistic simulations in a class of scalar-tensor theories with derivative self-interactions and screening of local scales. By using high-resolution shock-capturing methods and a nonvanishing shift vector, we have managed to avoid issues plaguing similar attempts in the past. We have first confirmed recent results by ourselves in spherical symmetry, obtained with an approximate approach and pointing at a partial breakdown of the screening in black-hole collapse. Then, we considered the late inspiral and merger of binary neutron stars. We found that screening tends to suppress the (subdominant) dipole scalar emission, but not the (dominant) quadrupole scalar mode. Our results point at quadrupole scalar signals as large as (or even larger than) in Fierz-Jordan-Brans-Dicke theories with the same conformal coupling, for strong-coupling scales in the MeV range that we can simulate.
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http://dx.doi.org/10.1103/PhysRevLett.128.091103 | DOI Listing |
J Colloid Interface Sci
December 2024
Department of Medicinal Chemistry, Uppsala University, P.O. Box 547, 751 23, Uppsala, Sweden. Electronic address:
We have investigated the effect of length and chemical structure of phospholipid tails on the spontaneous formation of unilamellar liposomal vesicles in binary solute mixtures of cationic drug surfactant and zwitterionic phosphatidylcholine phospholipids. Binary drug surfactant-phospholipid mixtures with four different phospholipids with identical headgroups (two saturated phospholipids 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC, 14:0) and 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC, 16:0), and two unsaturated lipids 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC, 18:1) and 1,2-Dierucoyl-sn-Glycero-3-Phosphatidylcholine (DEPC, 22:1)) combined with two different tricyclic antidepressant drugs (amitriptyline hydrochloride (AMT) and doxepin hydrochloride (DXP)) have been investigated with small-angle neutron scattering (SANS) and cryo-transmission electron microscopy (cryo-TEM). We observe a conspicuous impact of phospholipid tail structure on both micelle-to-vesicle transition point and vesicle size.
View Article and Find Full Text PDFInorg Chem
December 2024
Department of Chemistry, University of Toronto, 80 Saint George Street, Toronto, Ontario M5S-3H6, Canada.
Here it is demonstrated that there is a linear relationship between the terminal 3d metal hydride stretching wavenumber ν and the metal hydride distance reported to date: ν ∼ (-1.05 + 3.35) × 10 cm.
View Article and Find Full Text PDFProc SPIE Int Soc Opt Eng
February 2024
Radiation Monitoring Devices, Inc., 44 Hunt St., Watertown, MA, USA 02472- 4624.
Development of new scintillator materials is a continuous effort, which recently has been focused on materials with higher stopping power. Higher stopping power can be achieved if the compositions include elements such as Tl (Z=81) or Lu (Z=71), as the compounds gain higher densities and effective atomic numbers. In context of medical imaging this translates into high detection efficiency (count rates), therefore, better image quality (statistics, thinner films) or lower irradiation doses to patients in addition to lowering of cost.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
November 2024
The Radiology Department of Shanxi Provincial People's Hospital Affiliated to, Shanxi Medical University, Taiyuan, 030001, P. R. China.
Boron neutron capture therapy (BNCT) is an advanced binary tumor-cell-selected heavy-particle radiotherapy used for treating invasive malignant tumors. However, its clinical applications have been impeded by the rapid metabolism and insufficient tumor-specific accumulation of boron agents. To tackle this issue, we develop a smart boron nanosensitizer (BATBN) capable of transforming its size in response to cancer biomarker for optimal balance between penetration and retention of boron-10 for BNCT.
View Article and Find Full Text PDFJ Colloid Interface Sci
March 2025
Biological Physics Laboratory, Department of Physics and Astronomy, School of Natural Science, The University of Manchester, Oxford Road, Manchester M13 9PL UK. Electronic address:
Antimicrobial resistance (AMR) is fast becoming a major global challenge in both hospital and community settings as many current antibiotics and treatment processes are under the threat of being rendered less effective or ineffective. Synergistic combination of an antibiotic and an aiding agent with a different set of properties provides an important but largely unexploited option to 'repurpose' existing biomaterial's space while addressing issues of potency, spectrum, toxicity and resistance in early stages of antimicrobial drug discovery. This work explores how to combine tetracycline/minocycline (TC/MC) with a broad-spectrum antimicrobial lipopeptide that has been designed to improve the efficiency of membrane targeting and intramembrane accumulation, thereby enhancing antimicrobial efficacy.
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