An efficient methodology for the synthesis of a wide range of -CF imidic acid derivatives is presented. In this reaction, -CF nitrilium ions were generated -trifluoromethylation of nitriles using PhICFCl under catalysis with DMAP, followed by the capture of N-, O-, or S-centered nucleophiles to give diverse -CF amidines, imidates, and thioimidates. The method provides a platform for preparing -CF compounds with potential applications.
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| http://dx.doi.org/10.1021/acs.orglett.2c00647 | DOI Listing |
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