It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via dura-skull channels, and CSF proteins signal onto diverse cell types within the niches. After spinal cord injury, CSF-borne cues promote myelopoiesis and egress of myeloid cells into meninges. This reveals a mechanism of CNS-to-bone-marrow communication via CSF that regulates CNS immune responses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081158 | PMC |
| http://dx.doi.org/10.1038/s41593-022-01029-1 | DOI Listing |
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