Purpose: Benzoyl peroxide (BPO) is an effective acne treatment and has been used as a cleanser and short contact therapy. However, data on the minimum contact time of BPO needed to kill are lacking. Thus, the aim of this study was to determine the minimum contact time of commonly used BPO concentrations for bactericidal effects on .
Materials And Methods: An in vitro experimental study of clinically isolated was performed to determine the minimal inhibitory concentration (MIC) of BPO using the broth microdilution method. Subsequently, the minimum contact times of various concentrations of BPO were evaluated, and their bactericidal effects were assessed by the plate count method.
Results: The median MIC of BPO was 9375 µg/mL, which did not significantly differ between antibiotic-resistant and nonresistant . The minimum contact time of BPO with was significantly different among the BPO concentrations. For bactericidal activity against all isolates, 1.25%, 2.5%, 5%, and 10% BPO required 60 min, 15 min, 30 sec, and 30 sec, respectively.
Conclusion: BPO demonstrated bactericidal activity against both antibiotic-resistant and antibiotic-susceptible . The in vitro contact time needed to kill was almost immediate with 5% or more BPO, but ≤ 2.5% BPO required longer contact times for bactericidal effects.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922035 | PMC |
http://dx.doi.org/10.2147/CCID.S359055 | DOI Listing |
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!