Serves as a Potential Prognostic Marker and Correlates with Immune Infiltration in Lung Adenocarcinoma.

Background: B-cell translocation gene 2 () has been revealed to be involved in the occurrence and development of multiple cancers. However, the role of in lung adenocarcinoma (LUAD) is still ambiguous. Thus, this study aims to investigate the prognostic value of and its correlation with immune infiltration in LUAD.

Methods: The expression of in LUAD was analyzed using the TIMER and UALCAN databases. The correlations between expression and clinicopathological factors were investigated using the UALCAN databases. The Kaplan-Meier plotter, GEPIA, and TCGA databases were employed to assess the prognostic value of . The STRING database and Cytoscape software were used to construct an interaction network and mine co-expression genes. The TISIDB database was examined for a correlation between and driver genes in LUAD. Enrichment analysis of co-expressed genes and was performed using the LinkedOmics database. Finally, the correlations between and immune infiltrates were investigated using the TIMER, GEO, and TISIDB database.

Results: was significantly downregulated in LUAD. The decreased expression of in LUAD was significantly correlated with higher cancer stages and shorter duration of overall survival. The expressions of -related co-expression genes were associated with the prognosis in LUAD. The expression of was closely associated with the mutations of and . Enrichment analysis revealed that was significantly correlated with immune-associated signaling pathways and function. In addition, the expression of was found to be closely related to immune infiltration, multiple gene markers of immune cells, chemokines, and chemokine receptors.

Conclusion: Our findings have effectively demonstrated that expression was downregulated in LUAD, indicating poor prognosis. Closely relating to immune cell infiltration, may be a promising immune-related biomarker and molecular target for patients with LUAD.