AI Article Synopsis
- PBPK modeling has potential to enhance drug discovery, but recent studies show oral absorption models need significant improvement.
- There is a divide between industry and regulators regarding the trustworthiness of OA PBPK models.
- The article outlines new editorial guidelines on PBPK modeling which cover scientific writing, literacy, and middle-out approaches to enhance the models' effectiveness.
Article Abstract
Over the past few decades, physiologically-based pharmacokinetic modelling (PBPK) has been anticipated to be a powerful tool to improve the productivity of drug discovery and development. However, recently, multiple systematic evaluation studies independently suggested that the predictive power of current oral absorption (OA) PBPK models needs significant improvement. There is some disagreement between the industry and regulators about the credibility of OA PBPK modelling. Recently, the editorial board of AMDET&DMPK has announced the policy for the articles related to PBPK modelling (Modelling and simulation ethics). In this feature article, the background of this policy is explained: (1) Requirements for scientific writing of PBPK modelling, (2) Scientific literacy for PBPK modelling, and (3) Middle-out approaches. PBPK models are a useful tool if used correctly. This article will hopefully help advance the science of OA PBPK models.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920108 | PMC |
| http://dx.doi.org/10.5599/admet.923 | DOI Listing |
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