AI Article Synopsis
- Patients with haemophilia often experience joint pain due to repeated bleeding episodes, but there is a lack of comprehensive data on the prevalence rates of pain in this population.
- A systematic review identified 13 relevant studies, showing that approximately 40% of adult patients experience chronic pain, with a higher point prevalence of 75%, and moderate pain intensity being more common than extreme pain.
- The findings highlight the need for consistent definitions and measurements of pain types in haemophilia patients, suggesting that pain management strategies should differentiate between bleeding-related and joint damage-related pain.
Article Abstract
Objectives: Patients with haemophilia (PwH) often suffer from joint pain due to repetitive haemarthroses and resulting arthropathy. Literature focuses so far on pain causes, diagnosis or treatment. A summary of prevalence rates, providing facts on the absolute occurrence of pain, is not sufficiently described so far. This review aimed to explore and systematically review different pain conditions, focussing on prevalence rates of pain in adult PwH.
Methods: A review of English articles using PubMed and Web of Science was conducted in February 2020. The search strategy included patients with haemophilia A or B suffering from pain. The articles were selected based on defined PICOS-selection criteria.
Results: Out of 606 identified articles, 13 studies matched the given eligibility criteria and indicated pain prevalence rates. The weighted mean (WM) for the prevalence rate (varying timeframes) for chronic pain was 40% whereas for point prevalence the rate was WM=75%. Regarding pain intensity, findings of the EQ-5D-3L revealed moderate pain to be more present (61.0%) compared to extreme (11.6%). The main problem was the inconsistency of the definition of both acute and chronic pain as well as for prevalence types.
Conclusions: Pain is a major problem in patients with haemophilia. Pain therapy should be carried out taking into account the difference between bleeding-related or arthropathy-related causes of pain. In addition, the intensity and duration of pain should be recorded consistently to better monitor therapy and allow comparison with existing data.
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| http://dx.doi.org/10.1515/sjpain-2021-0158 | DOI Listing |
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