Augmented T -weighted steady state magnetic resonance imaging.

NMR Biomed

State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, Guangdong, China.

Published: August 2022

T contrasts obtained using short-TR incoherent steady state gradient echo (GRE) methods are generally suboptimal, to which non-T factors in the signals play a major part. In this work, we proposed an augmented T -weighted (aT W) method to extract the signal ratio between routine GRE T W and proton density-weighted signals that effectively removes the non-T effects from the original T W signals, including proton density, T * decay, and coil sensitivity. A recently proposed multidimensional integration (MDI) technique was incorporated in the aT W calculation for better signal-to-noise ratio (SNR) performance. For comparison between aT W and T W results, Monte Carlo noise analysis was performed via simulation and on scanned data, and region-of-interest (ROI) analysis and comparison was performed on the system phantom. For brain scans, the image contrast, noise behavior, and SNR of aT W images were compared with routine GRE and inversion-recovery-based T W images. The proposed aT W method yielded saliently improved T contrasts (potentially > 30% higher contrast-to-noise ratio [CNR]) than routine GRE T W images. Good spatial homogeneity and signal consistency as well as high SNR/CNR were achieved in aT W images using the MDI technique. For contrast-enhanced (CE) imaging, aT W offered stronger post-CE contrast and better boundary delineation than T MPRAGE images while using a shorter scan time.

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http://dx.doi.org/10.1002/nbm.4729DOI Listing

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