AI Article Synopsis

  • Single-factor interventions like exercise and sensory stimulation can help with Alzheimer’s disease (AD), but their effects are limited and not well-understood, prompting a study on multifactor interventions.
  • The study investigated the combined effects of voluntary exercise and acoustic-visual stimulation on neurogenesis and behavior in a mouse model of AD, finding significant improvements in new cell production and cognitive function after 4 weeks.
  • Results showed that multifactor interventions led to a higher differentiation of new cells into neurons and astrocytes, improved cognitive abilities, reduced anxiety and depression-like behaviors, altered protein levels linked to brain health, and positively impacted metabolites related to neuronal function.

Article Abstract

Single-factor intervention, such as physical exercise and auditory and visual stimulation, plays a positive role on the prevention and treatment of Alzheimer's disease (AD); however, the therapeutic effects of single-factor intervention are limited. The beneficial effects of these multifactor combinations on AD and its molecular mechanism have yet to be elucidated. Here, we investigated the effect of multifactor intervention, voluntary wheel exercise, and involuntary treadmill running in combination with acousto-optic stimulation, on adult neurogenesis and behavioral phenotypes in a mouse model of AD. We found that 4 weeks of multifactor intervention can significantly increase the production of newborn cells (BrdU cells) and immature neurons (DCX cells) in the hippocampus and lateral ventricle of Aβ oligomer-induced mice. Importantly, the multifactor intervention could promote BrdU cells to differentiate into neurons (BrdU DCX cells or BrdU NeuN cells) and astrocytes (BrdUGFAP cells) in the hippocampus and ameliorate Aβ oligomer-induced cognitive impairment and anxiety- and depression-like behaviors in mice evaluated by novel object recognition, Morris water maze tests, elevated zero maze, forced swimming test, and tail suspension test, respectively. Moreover, multifactor intervention could lead to an increase in the protein levels of PSD-95, SYP, DCX, NeuN, GFAP, Bcl-2, BDNF, TrkB, and pSer473-Akt and a decrease in the protein levels of BAX and caspase-9 in the hippocampal lysates of Aβ oligomer-induced mice. Furthermore, sequencing analysis of serum metabolites revealed that aberrantly expressed metabolites modulated by multifactor intervention were highly enriched in the biological process associated with keeping neurons functioning and neurobehavioral function. Additionally, the intervention-mediated serum metabolites mainly participated in glutamate metabolism, glucose metabolism, and the tricarboxylic acid cycle in mice. Our findings suggest the potential of multifactor intervention as a non-invasive therapeutic strategy for AD to anti-Aβ oligomer neurotoxicity.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12035-022-02784-9DOI Listing

Publication Analysis

Top Keywords

multifactor intervention
24
aβ oligomer-induced
12
combination acousto-optic
8
acousto-optic stimulation
8
stimulation adult
8
adult neurogenesis
8
mouse model
8
intervention
8
single-factor intervention
8
cells brdu
8

Similar Publications

Background: High-quality bowel preparation is paramount for a successful colonoscopy. This study aimed to explore the effect of artificial intelligence-driven smartphone software on the quality of bowel preparation.

Methods: Firstly, we utilized 3305 valid liquid dung images collected mobile phones as training data.

View Article and Find Full Text PDF

This study investigated the effect of Luoshi Neiyi Formula(LSNYF) on hypoxia-inducible factor-1α(HIF-1α) and steroidogenic factor 1(SF-1) in endometriosis(EMs), aiming to explore the mechanism of Luoshi Neiyi Formula in treating EMs. Immunohistochemistry and quantitative real-time PCR(qPCR) were employed to determine the expression of HIF-1α and SF-1 in the endometriotic tissue. Human primary endometrial stromal cells(ESCs) were extracted and identified, in which the expression levels of HIF-1α and SF-1 were measured by immunofluorescence and qPCR.

View Article and Find Full Text PDF

To achieve a more precise delineation of ecosystem sensitivity control areas, this study examines the Mentougou District in Beijing and introduces the Ecosystem Sensitivity Control Area Classification Method (ESCACM). This novel approach combines single-factor sensitivity analysis, multi-factor comprehensive sensitivity assessments, and strategies for zoning based on various ecological scenarios. The study categorizes the region into three specific zones: first-level management and control areas, second-level management and control areas, and non-management and control areas.

View Article and Find Full Text PDF

Objective: To construction the risk factors associated with prolonged hospitalization in patients with severe acute pancreatitis (SAP) and develop a prediction model for assessing these risks.

Methods: SAP patients admitted to the department of emergency of Hebei Province Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from January 2015 to December 2023 were retrospectively selected as the study subjects. The 75% of hospital stay was used as the cut-off point, and the patients were categorized into a normal group and an extended group.

View Article and Find Full Text PDF

Background: Disulfidptosis, identified as an innovative form of cellular death subsequent to cuproptosis, is currently under investigation for its mechanisms in oncological contexts. In-depth analyses exploring the relationship between disulfidptosis-related genes (DRGs) and hepatocellular carcinoma (HCC) are currently limited.

Methods: Transcriptomic data and clinical information were retrieved from the TCGA and GEO databases (GSE76427 and GSE54236), concentrating on the expression levels of 24 DRGs.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!