AI Article Synopsis
- - Gastric cancer (GC) is a common cancer type, often spreading to the liver, and the role of the AMIGO2 protein in this type of cancer was investigated.
- - Researchers analyzed AMIGO2 expression in 128 GC patients using immunohistochemistry and found it to be linked to survival and liver metastasis outcomes.
- - The findings suggest that AMIGO2 levels in GC tissues can serve as a predictor for patient prognosis and the likelihood of liver metastasis.
Article Abstract
Background: Gastric cancer (GC) is one of the most common malignancies, and the liver is the most common site of hematogenous metastasis of GC. AMIGO2 is a type I transmembrane protein that has been implicated in tumour cell adhesion in adenocarcinomas; however, its importance in GC remains undetermined.
Methods: We analyzed AMIGO2 expression by immunohistochemistry using the specific monoclonal antibody for human AMIGO2 in 128 patients who underwent GC surgery to evaluate its relationship between various metastatic and clinical outcomes in GC.
Results: Immunohistochemistry revealed that AMIGO2 expression was an independent prognostic factor for overall survival, disease-specific survival, and liver metastasis in GC patients.
Conclusions: This study showed that AMIGO2 is induced in GC tissues and can mediate hepatic metastasis. Determining AMIGO2 expression in GC will help predict patient prognosis and the incidence of liver metastasis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8925171 | PMC |
| http://dx.doi.org/10.1186/s12885-022-09339-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Perineuronal nets on CA2 pyramidal cells and parvalbumin-expressing cells differentially regulate hippocampal dependent memory.
bioRxiv
November 2024
Neurobiology Laboratory, National Institute of Environmental Health Sciences, Division of Intramural Research, National Institute of Health, Research Triangle Park, North Carolina 27713, USA.
Perineuronal nets (PNNs) are a specialized extracellular matrix that surround certain populations of neurons, including (inhibitory) parvalbumin (PV) expressing-interneurons throughout the brain and (excitatory) CA2 pyramidal neurons in hippocampus. PNNs are thought to regulate synaptic plasticity by stabilizing synapses and as such, could regulate learning and memory. Most often, PNN functions are queried using enzymatic degradation with chondroitinase, but that approach does not differentiate PNNs on CA2 neurons from those on adjacent PV cells.
View Article and Find Full Text PDFPrevention of liver metastasis via the pharmacological suppression of AMIGO2 expression in tumor cells.
Sci Rep
November 2024
Division of Experimental Pathology, Faculty of Medicine, Tottori University, 86 Nishicho, Yonago, 683-8503, Japan.
Article Synopsis
- AMIGO2 is a protein that facilitates liver metastasis in tumor cells, and altering its expression impacts the cells’ ability to metastasize.
- The study aimed to find ways to reduce liver metastasis by lowering AMIGO2 levels, testing 285 compounds and identifying five that effectively inhibit tumor cell adhesion to the liver.
- Among these, the clinically available drug ruxolitinib was found to significantly reduce AMIGO2 expression and could effectively prevent liver metastasis in both mouse and human cancer cells.
AMIGO2 characterizes cancer-associated fibroblasts in metastatic colon cancer and induces the release of paracrine active tumorigenic secretomes.
J Pathol
January 2025
Division of Molecular and Experimental Surgery, Department of Surgery, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.
Secretomes of cancer-associated fibroblasts (CAFs) in colorectal cancer (CRC) contribute to malignancy. Detailed knowledge is available on the components and functions of CAF secretomes. Little is known about the regulation of CAF secretomes.
View Article and Find Full Text PDFAMIGO2 enhances the invasive potential of colorectal cancer by inducing EMT.
Cancer Gene Ther
December 2024
Division of Experimental Pathology, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan.
Article Synopsis
- Researchers identified AMIGO2 as a key driver gene in liver metastasis and poor outcomes for colorectal cancer (CRC) patients.
- The study explored how AMIGO2 promotes epithelial-mesenchymal transition (EMT), which enhances the invasion potential of CRC cells, primarily through the activation of the TGFβ/Smad signaling pathway.
- Findings indicate that AMIGO2 is significantly expressed in the invasive front of tumors and its nuclear presence is linked to EMT marker expression, suggesting it could be targeted for therapies aiming to inhibit metastasis in CRC.
Role of AMIGO2 in cancer progression: Novel insights (Review).
Oncol Lett
September 2024
Department of Oncology, Huishan Third People's Hospital of Wuxi, Wuxi, Jiangsu 214183, P.R. China.
Article Synopsis
- AMIGO2 is a special protein found in brain cells that helps keep neurons alive by stopping them from dying too soon.
- It is also found in many types of cancer, like stomach and skin cancer, and can help tumors grow and spread.
- The text talks about new research on AMIGO2 to find ways to create better treatments for cancer by targeting this protein.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!