Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants.

Background: Childhood overweight and obesity (OW/OB) is a worldwide public health problem, and its genetic risks remain unclear.

Objectives: To investigate risks of OW/OB associated with genetic variances in rs543874 and rs10913469, rs11030104 and rs6265, rs11191580, rs11165675, rs2531995, rs7869969, rs2237892, and rs2968990 in Chinese infants at 12-month old.

Methods: We conducted a case-control study with 734 infants included at delivery and followed up to 12-month old. The classification and regression tree analysis were used to generate the structure of the gene-gene interactions, while the unconditional multivariate logistic regression models were applied to analyze the single SNP, gene-gene interactions, and cumulative effects of the genotypes on OW/OB, adjusted for potential confounders.

Results: There were 219 (29.84%) OW/OB infants. Rs543874 G allele and rs11030104 AA genotype increased the risk of OW/OB in 12-month-old infants ( < 0.05). Those carrying both rs11030104 AA genotype and rs10913469 C allele had 4.3 times greater OW/OB than those carrying rs11030104 G allele, rs11191580 C allele, rs11165675 A allele, and rs543874 AA genotype. Meanwhile, the risk of OW/OB increased with the number of the risk genotypes individuals harbored.

Conclusions: Rs543874, rs11030104, and rs11191580 were associated with OW/OB in 12-month-old Chinese infants, and the three SNPs together with rs10913469 and rs11165675 had a combined effect on OW/OB.