Ethambutol-induced bullous skin lesions in lung infection.

Int J Mycobacteriol

Salem VA Medical Center, Salem, VA; Virginia Tech Carilion School of Medicine, Roanoke, Virginia; Department of Infectious Disease, Salem VA Medical Center, Salem, VA, USA.

Published: May 2022

AI Article Synopsis

  • - Mycobacterium kansasii is the second most common cause of non-tuberculous mycobacterial lung disease in the U.S., after Mycobacterium avium complex infection.
  • - The standard treatment consists of a three-drug regimen: rifampin, isoniazid, and ethambutol.
  • - Patients on this treatment can develop side effects like bullous skin lesions, necessitating a coordinated approach to identify second-line treatments if they experience intolerance to the first-line antibiotics.

Article Abstract

Mycobacterium kansasii is the second most common cause of nontuberculous mycobacterial (NTM) lung disease after Mycobacterium avium complex infection in the United States. The first-line therapy for M. kansasii is a three-drug regimen including rifampin, isoniazid, and ethambutol. We present a case of a patient with pulmonary M. kansasii who developed bullous skin lesions while receiving this regimen and again after rechallenge with ethambutol. In patients with intolerance to one of the first-line antibiotics, a multidisciplinary team approach to starting second-line agents is needed. Ethambutol should be included in the differential diagnosis of drug-induced bullous skin lesions in treated patients with NTM, who develop new onset rash with blisters or ulceration.

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Source
http://dx.doi.org/10.4103/ijmy.ijmy_204_21DOI Listing

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